A domino protocol for the efficient synthesis of structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues

Arya, Anand Kumar; Gupta, Sunil Kumar; Kumar, M.

doi:10.1016/j.tetlet.2012.08.099

Cited by 26 publications

(9 citation statements)

References 22 publications

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“…Condensations of 5-amino-3-methylpyrazole ( 4 ) (Lipson and Gorobets, 2009 ; Zhong et al, 2013 ) or 5-amino-3-methyl- N -phenylpyrazole ( 21 ) (Shi et al, 2011 ) with aldehydes 1 or arylglyoxals (Petrova et al, 2014 ) and Meldrum's acid 45 under various conditions gave 5-pyrimidinones 52a and 53a , correspondingly (Figure 4 ); similar heterocycles were obtained from 2-aminobenzothiazole (Arya et al, 2012 ).…”

Section: Main Partmentioning

confidence: 78%

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

et al. 2018

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Section: Main Partmentioning

confidence: 78%

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

et al. 2018

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“…180 Replacing Meldrum's acid with barbituric acid in this reaction using SO 3 H-functionlized halogen-free ionic liquid 3-methyl-1-(butyl-4-sulfonyl)imidazolium hydrogen sulphate ([MIM(CH 2 ) 4 …”

Section: Scheme 97mentioning

confidence: 99%

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

Ziarani¹,

Moradi²,

Lashgari³

2015

Arkivoc

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Isatin has been utilized in many heterocyclic preparations and considered as an important building block in organic synthesis. There is a wide range of multi-component reactions that include isatin in the synthesis of heterocyclic compounds. This review highlights the advances in the use of isatin as starting material in the synthesis of various organic compounds and drugs during the period from 2012 to 2015.

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“…The present synthetic methodology involves the reaction of phenylhydrazine, with o-aminoacetophenone and cyclic ketones using nanostructured Terbium doped TiO 2 as recyclable and reusable heterogeneous catalyst. In view of medicinal importance of isocryptolepine structural framework and our research interest in the synthesis of drug-like hybrid molecules with privileged heterocyclic structures, [34][35][36][37][38][39][40][41][42][43][44][45] the present synthetic protocol is probably the first report for the synthesis of spiroannulated indolo […”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of terbium doped TiO₂ nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐c]quinolines‐ mimetic scaffolds of isocryptolepine

Verma

Tailor

Khandelwal

et al. 2020

Applied Organom Chemis

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An efficient and environmentally sustainable domino protocol has been presented for the synthesis of structurally diverse spiroannulated indolo[3,2‐c]quinolines involving three component sequential reaction of phenylhydrazine, o‐aminoacetophenone and cyclic ketones using nanostructured terbium doped TiO2 as recyclable and reusable heterogeneous catalyst. The nanostructured catalyst was synthesized successfully and characterized by X‐ray Diffraction (XRD), transmission electron microscopy (TEM), EDX and Fourier transform infra‐red spectroscopy (FTIR). The substitution of Ti+4 with Tb+3 and the formation of Ti‐O‐Tb bonds as a result of doping of Terbium with TiO2 NPs increases the catalytic efficiency and facilitates the reaction to provide the products in excellent yields. The present protocol with special features; operational simplicity, atom‐economy, mild reaction conditions, environmental sustainability and high synthetic efficiency with recyclability and reusability of catalyst has been reported for the first time to synthesize spiroannulated indoloquinolines and expecting to provide the library of promising new leads in drug discovery research.

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A domino protocol for the efficient synthesis of structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues

Cited by 26 publications

References 22 publications

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

Synthesis and characterization of terbium doped TiO₂ nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐c]quinolines‐ mimetic scaffolds of isocryptolepine

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A domino protocol for the efficient synthesis of structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues

Cited by 26 publications

References 22 publications

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

Synthesis and characterization of terbium doped TiO2 nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐c]quinolines‐ mimetic scaffolds of isocryptolepine

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Synthesis and characterization of terbium doped TiO₂ nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐c]quinolines‐ mimetic scaffolds of isocryptolepine