A donor's a person, no matter how small

Pulsipher, Michael A.

doi:10.1182/blood-2012-01-400770

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Also, cardiovascular complications can occur after general anesthesia is used for catheter insertion (stem cell harvest) or for bone marrow collection from the hip [23, 27, 28]. The donors in the highest risk for complications were less than four years old, as in the case of our donor [28]. In 1987, for instance, a brother, who was 19 months old and HLA-compatible, donated his bone marrow to his older sister.…”

Section: The Bioethical Problem and The Bioethical Committeementioning

confidence: 99%

“…Our decision for the donation was based on the recommended criteria bellow [25, 27, 28, 30]:Hospital Israelita Albert Einstein is a HSCT referral center;The donor would have a multidisciplinary pediatrician team to do the prior transplant evaluation and the systematic follow-up after that;The donor and her family would have psychological evaluation and support prior to and after to transplant;Donor risk would not be significant, based on scientific studies and clinical practice in our hospital;Without the transplantation, there was a severe risk of death and complications in our SCD patient at that time. The boy could not wait for his sister to get older;…”

Section: The Bioethical Problem and The Bioethical Committeementioning

confidence: 99%

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A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease

Pereira

Hellman

Hamerschlak

et al. 2017

Case Reports in Hematology

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Hematopoietic stem cell transplantation (HSCT) is an important treatment option for children with severe and refractory sickle cell disease (SCD) with debilitating clinical complications. HSCT with cells from the bone marrow of a HLA-identical sibling used in SCD has a low mortality risk, high cure rate, and high event-free survival rate after a median follow-up of 5-6 years. However, matched donors are found in only about 20% of the patients. A boy aged 8 years with SCD had a sister, <2 years old, a fully compatible donor. The boy met all eligibility criteria to undergo HSCT, and he was suffering from cognitive and neurologic impairment due to ischemic events. A Bioethical Committee jointly discussed the ethical issues on this case after a pediatric evaluation released the very young sister for donation. The justification was that the sister would benefit from the donation too because of the greater likelihood of survival and cure and less suffering of her brother. The parents were informed about the risks and benefits for both children, and the family was psychologically evaluated. After their consent, HSCT was performed and the patient is cured from SCD. The complication for the donor was the need for blood transfusion.

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Section: The Bioethical Problem and The Bioethical Committeementioning

confidence: 99%

Section: The Bioethical Problem and The Bioethical Committeementioning

confidence: 99%

A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease

Pereira

Hellman

Hamerschlak

et al. 2017

Case Reports in Hematology

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“…An area in which UD registries could have a role in pediatric donor care immediately lies in provision of post-donation follow-up. Several parties have stressed the importance of longterm follow-up of pediatric donors, 16,18 which is not currently performed and long-term monitoring becomes even more necessary if children are treated with G-CSF. 17,19 COULD DONOR REGISTRIES MEET THE PSYCHOLOGICAL NEEDS OF RDS?…”

Section: Could Registries Manage Pediatric Rds?mentioning

confidence: 99%

Related hematopoietic cell donor care: is there a role for unrelated donor registries?

Anthias

Walraven

Sørensen

et al. 2015

Bone Marrow Transplant

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In almost half of allogeneic hematopoietic progenitor cell (HPC) transplants, a related donor (RD) is used, yet a lack of standardized guidelines means that their care is heterogeneous. Changes to regulatory standards aim to improve uniformity, but adherence to these regulations can prove logistically difficult for the transplant centers (TCs) managing RDs. Discussion has ensued around possible alternative models of related donor care and a session at the European Society for Blood and Marrow Transplantation (EBMT) annual meeting in 2013 debated the question of whether a role exists for unrelated donor registries in the management of 'related' donors. In this overview, we discuss the issues raised at this debate and the pros and cons of donor registry involvement in various aspects of RD management. By examining existing models of related donor care that have been adopted by members of the World Marrow Donor Association (WMDA), we look for ways to enhance and homogenize RD care, while also enabling transplant centers to meet standards required for mandatory accreditation.

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Children as Tissue Donors

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A donor's a person, no matter how small

Cited by 9 publications

References 9 publications

A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease

A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease

Related hematopoietic cell donor care: is there a role for unrelated donor registries?

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