A double-blind, randomised, parallel-group trial was cant falls in heart rate. Both active drugs were well tolerconducted in patients with essential hypertension in ated, nebivolol marginally more so. Nebivolol, a longBritish general practices, of nebivolol 5 mg, atenolol acting, cardioselective, vasodilating beta-blocker which 50 mg, and placebo each given once daily. Both active acts partly via the l-arginine/nitric oxide mechanism, drugs, in comparison with placebo, caused highly sigappears potentially valuable for the treatment of hypernificant and similar reductions in systolic and diastolic tension. pressures without orthostatic effect, and small signifiKeywords: nitric oxide; quality of life; side effects daily were begun. After 4 weeks of this single-blind