“…Recently, estrogen has played an important role in the preventative health care of postmenopausal women. The use of estrogens for the relief of vasomotor symptoms, improvement of vaginal discomfort due to atrophy (6), and the prevention of osteoporosis (7) and cardiovascular diseases (8) is now well established. It has also been reported that each tissue has a different sensitivity to estradiol (9,10).…”