A double-blind, crossover study of Biotene Oralbalance and BioXtra systems as salivary substitutes in patients with post-radiotherapy xerostomia

Shahdad, Shakeel; Taylor, Cindy C.; Barclay, Stewart; Steen, IN; Preshaw, P.M.

doi:10.1111/j.1365-2354.2005.00587.x

Cited by 83 publications

(105 citation statements)

References 17 publications

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“…The suggested reason for this skewed gender differentiation is based upon the premise that more females are diagnosed because they are more likely than males to visit outpatient clinics when they recognize they have abnormal symptoms [7,16,23,24].…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Combination Saliva Substitute for the Management of Xerostomia and Hyposalivation

Lapiedra

Gómez

Sánchez

et al. 2015

J. Maxillofac. Oral Surg.

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Objective The objective of this study was to evaluate the difference between the combination agent of xylitol, beatine and olive oil in a chewable capsule versus the control agent of a sorbitol tablet in subjects with hyposalivation and xerostomia. Materials and Methods The subjects had xerostomia over 3 months and a measured hyposalivation. The study was 3 weeks in duration, with 2 treatment phases of 1 week and a 7 day wash out period in between. At the end of each treatment phase, subjects returned for a follow up evaluation. At this visit they were given the subjective sensation questionnaire, as well as their unstimulated whole salivary flow and stimulated whole salivary flow were measured. Results There was a greater increase in the unstimulated and stimulated whole salivary flow rate, although the results were not statistically significant. The subjective evaluation as measured by the questionnaire showed that both agents reduced the mean score as compared to the baseline, although only the findings in the active agent was statistically significant (p = 0.0015). Conclusion The significant conclusions found in this study were that the active agent provided a significant subjective improvement in speech, swallowing, and decreased subjective xerostomia as compared to the control tablet. Clinical Relevance This combination agent has a significant effect on patients with subjective xerostomia but does not have a significant effect on objective hyposalivation.

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Section: Discussionmentioning

confidence: 99%

The Effect of a Combination Saliva Substitute for the Management of Xerostomia and Hyposalivation

Lapiedra

Gómez

Sánchez

et al. 2015

J. Maxillofac. Oral Surg.

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“…En los casos que las medidas anteriores no hayan tenido la eficacia esperada o para tratamientos concomitantes con los anteriores o ante la ausencia total de parénquima glandular residual remanente, el único medio que tenemos a nuestro alcance para mejorar la calidad de vida de estos pacientes es la utilización de productos que remeden a la saliva, tenemos desde los sistemas con complejos lactoperoxidasa, a toda una nueva línea de productos que contienen aceite de oliva, betaína y xilitol, que persiguen por un lado lubricar la cavidad oral, dotándola de una capacidad tampón y así evitar gran parte de los efectos secundarios que produce la ausencia de saliva, como son la aparición de caries o de infecciones fúngicas, y, por otro lado, mejorar la capacidad deglutoria y fonatoria de los pacientes afectados (10). De entre los muchos sustitutos salivales, tan solo dos, según refiere López-López et al (2), presentan estudios bien estructurados, son los del grupo OralBalance® y el Xerostom®.…”

Section: Sustitutos Salivalesunclassified

Tratamiento de la boca seca: nuevas tendencias

et al. 2014

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Jané Salas E, Estrugo Devesa A, Ayuso Montero R, López López J. Tratamiento de la boca seca. Nuevas tendenciasAVANCES EN ODONTOESTOMATOLOGÍA/135 INTRODUCCIÓNLa boca seca es un problema de magnitud creciente y que conlleva una serie de alteraciones que afectan, en último término, la calidad de vida de los pacientes; es por ello que su tratamiento supone un reto para el profesional (1). La orientación terapéutica así como su pronóstico depende de la etiología que origina el problema. Los tratamientos deben enfocarse diferenciando las causas transitorias de las permanentes, así como de la cantidad de parénqui-ma glandular funcional remanente del paciente. A lo Tratamiento de la boca seca. Nuevas tendencias Treatment of dry mouth. New trendsJané Salas E*, Estrugo Devesa A*, Ayuso Montero R**, López López J* RESUMEN La disminución de saliva afecta la calidad de vida de los pacientes, que pueden mejorar cambiando ciertos hábitos de salud general como hidratación, uso de humidificadores ambientales, evitar tóxicos y conductas saludables, incluyendo visitas frecuentes al dentista. La prevención en los pacientes que van a ser irradiados, la modificación de los fármacos xerostomizantes en los casos posibles contribuyen al bienestar de estos pacientes. Los diferentes métodos de estimulación salivar tanto farmacológicos (ácidos, pilocarpina) como no farmacológicos (mecánicos, eléctricos, láser, acupuntura u oxígeno hiperbárico) y el uso de sustitutos salivales ayudan a mantener mejor hidratación bucal. En el futuro, el desarrollo de componentes orgánicos a partir de células madre será probablemente una posibilidad de tratamiento efectiva.Palabras clave: Tratamiento de la boca seca, boca seca. SUMMARYDecreased saliva affects patients quality of life, that can improve changing certain health habits like hydration, usin groom humidifiers, avoid toxics and healthy behaviors, including frequent visits to the dentist. Prevention in patients who are going to be irradiated and modify xerostomizing drugs where possible contribute to the welfare of these patients. Different salivary stimulation methods, both pharmacological (acid, pilocarpine) and non-pharmacological (mechanical, electrical, laser, acupuncture or hyperbaric oxygen) and the use of salivary substitutes help maintain oral moisture better. In the future, the development of organic components from stem cells will probably be a valid line of treatment.

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“…Oralbalance® (Laclede, Inc., Rancho Dominguez, CA, USA), which is a commercially available saliva substitute, has been reported to alleviate the symptoms of post-radiotherapy xerostomia in head and neck cancer patients [4,8]. Therefore, this product may be effective in HCT patients.…”

Section: Introductionmentioning

confidence: 99%

Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation

Sugiura

Soga

Yamabe

et al. 2009

Support Care Cancer

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2 AbstractPurpose: The commercial saliva substitute Oralbalance® has been reported to alleviate symptoms of post-radiotherapy xerostomia in head and neck cancer patients. Oralbalance® may also be effective for xerostomia in patients undergoing hematopoietic cell transplantation (HCT) with high-dose chemotherapy and total-body irradiation. However, HCT patients are in a severely compromised condition, and saliva substitute must not promote infection. We reported previously that Oralbalance® has anti-microbial effects against microbial species detected during HCT in vitro. This study was performed to determine the in vivo effects of Oralbalance® on oral mucosal total bacterial counts in patients undergoing HCT.Methods: A total of 18 neutropenic patients undergoing HCT were enrolled in this study. Before and after 1 week of Oralbalance® use, bacterial samples were obtained from patients by wiping an area of φ1 cm on the buccal mucosa with sterilized cotton swabs. Total bacterial counts of the obtained samples were examined by quantitative polymerase chain reaction amplification of the bacterial 16S ribosomal RNA gene. As controls, bacterial samples were also obtained from 10 healthy subjects, and total bacterial counts were examined.Results: No significant increase in bacterial count was observed with use of Oralbalance®. None of the patients showed bacterial counts above the range found in healthy controls after using Oralbalance®. Conclusions:In neutropenic patients undergoing HCT, Oralbalance® did not increase the total counts of oral mucosal bacteria beyond the range found in healthy controls. Oral care using Oralbalance® may alleviate the symptoms induced by hyposalivation without promoting infection.

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A double-blind, crossover study of Biotene Oralbalance and BioXtra systems as salivary substitutes in patients with post-radiotherapy xerostomia

Cited by 83 publications

References 17 publications

The Effect of a Combination Saliva Substitute for the Management of Xerostomia and Hyposalivation

The Effect of a Combination Saliva Substitute for the Management of Xerostomia and Hyposalivation

Tratamiento de la boca seca: nuevas tendencias

Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation

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