A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes

Jayawardena, Manika; Alwis, Nimantha Mark Wilfred de; Hettigoda, V.; Fernando, D

doi:10.1016/j.jep.2004.10.026

Cited by 106 publications

(79 citation statements)

References 9 publications

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“…6) The aqueous extract of KT stems (KTE) or roots is currently used as a herbal therapy for diabetes mellitus in Sri Lanka. 7) The boundary between food and medicine has been explored, and functional foods have recently emerged as one of the key concepts in the food industry worldwide. 8,9) Hence, many people in the United States, Japan, and other industrial countries are consuming traditional medicinal plants as dietary supplements and herbal tea for preventing diseases and maintaining good health.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice

Miyata

Nakatani

et al. 2008

JOURNAL OF HEALTH SCIENCE

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Kothala himbutu (KT) is a traditional medicinal plant used in treating diabetes in Ayurvedic medicine. We investigated the effect of the aqueous extract of KT stems (KTE) on energy expenditure in normal mice. Male C57BL/6J mice (n = 28) were divided into 4 groups depending on the type of diet they were fed for 9 weeks: normal (N) diet group (N: 13.8% energy in the form of fat), high-fat (HF) diet group (HF: 53.0% energy in the form of fat), 0.1% freeze-dried KTE (KTED)-supplemented N diet group (N+KTED), and 0.1% KTED-supplemented HF diet group (HF+KTED). KTED intake significantly reduced body weight gain in mice in the N and HF groups. Although it did not affect the plasma levels of glucose, triglyceride, and nonesterified fatty acid, KTED significantly decreased the HF diet-induced increased plasma insulin level. The epididymal and perirenal white adipose tissue (WAT) weights were significantly lower in the HF+KTED group than in the HF group. The oxygen consumption (VO 2 ), measured by indirect calorimetry, of the mice in the KTED-supplemented groups was significantly higher than that of the mice in the N and HF control groups. Moreover, KTED significantly reduced the size of epididymal WAT adipocytes in the N and HF groups. Thus, KTED promoted VO 2 and suppressed WAT accumulation in the mice on the N and HF diets. Therefore, KTE is beneficial in reducing N diet-and HF diet-induced obesity, which may be partly attributable to the stimulation of whole body energy metabolism.

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Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice

Miyata

Nakatani

et al. 2008

JOURNAL OF HEALTH SCIENCE

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“…[37][38][39][40] The hypoglycemic properties of these compounds have been evaluated and demonstrated in animal models [41,42] as well as in humans. [43] For instance, the amino acid derivative, S-methyl cysteine sulphoxide and S-alkyl cysteine sulphoxide content in Allium cepa (Onion), [44] Allium sativum (Garlic) [45] stimulates insulin secretion, whereas Charantin (a peptide) [46] inhibits hepatic glycogenolysis. Lipid components such as phytosterols [47] stimulate insulin biosynthesis and secretion; β-sitosterol suppresses glucose-6-phosphatase and promotes glycogen biosynthesis with reduced phosphorylase activity.…”

Section: Discussionmentioning

confidence: 99%

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera).

Okey¹,

Chidoka²

2014

Phcog Commn.

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“…Although useful in themselves they do not appear to have led to the formulation of therapeutically useful clinical products for diminishing sperm motility or for management of diabetes. In contrast, a polyherbal manufactured formulation using Salacia reticulata (Kothala himbutu) has been tested in an RCT and found to be useful in type 2 diabetes as an adjunct to glibenclamide and metformin in standard dosage [19]. However, this formulation had not been registered as a herbal medicine by the Department of Ayurveda at the time of the RCT or its publication, as far as I have been able to ascertain.…”

Section: Leading Articlementioning

confidence: 99%

Clinical research with traditional herbal medicines

Goonaratna

2013

Ceylon Med. J.

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Clinical research with traditional herbal medicinesEvidence-based medicine (EBM) is the new nostrum, and the randomised controlled trial (RCT) is the chosen device for buttressing its evidence base. Evidence, in the context of decision-making about therapeutic interventions, serves one purpose: it is the medium of establishing their efficacy for clinicians involved in the care of patients' life and health, and their rightness for experts charged with the responsibility for taking decisions with regard to therapeutic guidelines, public health interventions and health care systems.The long-standing dispute about the nature of science and scientific method, with respect to the inductive and deductive approaches to scientific knowledge, continues unabated. Recent attempts to stratify evidence into hierarchies based on 'levels' of sources and perceptions of quality have intensified the controversy pertaining to the relative merits of experimentation versus observation in the domain of modern therapeutics. The Scottish Intercollegiate Guideline Network (SIGN) is a typical example of a hierarchy of evidence [1]. All hierarchies place RCTs at the pinnacle, with observational studies languishing in the lower regions, and 'expert opinion' at the bottom. Hierarchies of evidence are now widely regarded as reliable measures of relative 'strength' of evidence in therapeutics, and used -particularly by committees that develop guidelines -to rank therapeutic interventions' merit, based on their perceived robustness. There is no gainsaying of course that popular acceptance of EBM has transformed medical practice and research preponderantly for the better, but the widespread and mechanical use of hierarchies of evidence has also raised many questions [2]. The findings of a single RCT or a systematic review of several will give evidence about the efficacy of an intervention (ie. 'the particular treatment has worked somewhere'), very often without supplying testimony regarding its clinical effectiveness in actual practice (ie. 'the treatment works extensively'), or its efficiency (ie. 'is it worth it?') [3,4,5].Most RCTs test efficacy with carefully selected patients, numerous exclusion criteria, absence of co-morbidities, intensely supervised treatment, monitored patient compliance and careful follow up -ideal conditions rarely available in actual clinical practice in which effectiveness and efficiency are important considerations [3,5,6]. RCT evidence is often not generalisable to certain groups of people, individuals, or different settings. Often RCT evidence also fades with time. To choose one example from the many available, older antipsychotic medications have been shown in large well-designed trials to be as effective as the newer ones (eg. olanzepine, risperidone etc.), and cost much less, alas! after widespread prescription of the newer drugs had made fortunes for their manufacturers [2].Among the large number of distinguished clinicians and scientists who have expressed serious misgivings about such hierarchies of evidenc...

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A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes

Cited by 106 publications

References 9 publications

Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice

Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera).

Clinical research with traditional herbal medicines

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