A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility

Kessopoulou, Efrossini; Hj, Powers; Sharma, K.K.; Pearson, Michael J.; Russell, Jean; Cooke, I. D.; Barratt, Christopher L.R.

doi:10.1016/s0015-0282(16)57861-3

Cited by 307 publications

(174 citation statements)

References 19 publications

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“…For example, some studies have shown that vitamin C, vitamin E, zinc, folic acid, and selenium alone or in combination could improve sperm parameters, especially sperm motility and sperm DNA integrity (36)(37)(38)(39). In contrast, several reports refute the effects of these antioxidants on sperm parameters (40,41).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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Background: Oxidative stress is the result of an imbalance between the production and scavenging of reactive oxygen species (ROS). Recently, oxidative stress has been introduced as a major cause of male infertility. Objectives: The aim of the present study was to determine the correlation between total antioxidant capacity (TAC) and malondialdehyde (MDA) as markers of oxidative stress in relation to idiopathic male infertility and sperm parameters. Patients and Methods: This case control study was conducted using 35 men with idiopathic infertility and 34 men with proven fertility. Seminal plasma TAC and MDA were measured by ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods, respectively. Results: Seminal TAC levels were significantly lower and seminal MDA levels were significantly higher in men with idiopathic infertility than in fertile men (P < 0.0001 and P = 0.004, respectively). A positive correlation was shown between sperm motility, sperm morphology, and TAC levels in men with idiopathic infertility (P = 0.002 and P = 0.002, respectively). In addition, there was a correlation between sperm motility and TAC levels in fertile men (P = 0.005). There was no correlation between sperm count and TAC levels in either men with idiopathic infertility or in fertile men. Negative correlations were observed between MDA levels and sperm motility, morphology, and sperm count only in men with idiopathic infertility (P = 0.003, P = 0.001, and P = 0.006, respectively). Conclusions: Our results show that oxidative stress could play an important role in male infertility as well as in sperm motility and sperm morphology.

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Section: Discussionmentioning

confidence: 99%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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“…Only four of these studies [28][29][30][31] found little or no effect on semen parameters, whereas beneficial effects were reported in the remaining 18 studies. 8,19,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] In vitro studies.…”

Section: Vitamin Ementioning

confidence: 99%

“…In 1995, Kessopoulou et al 28 and Moilanen and Hovatta 29 administered vitamin E 600 mg day 21 for 3 months and 600, 800 or 1200 mg day 21 for 3 weeks, respectively, finding increased concentrations of vitamin E in plasma and semen but no changes in semen parameters. In 1996, Geva et al 30 conducted a prospective study on 15 antiretroviral therapy patients, in which the administration of 200 mg day 21 for 3 months produced no changes in sperm morphology.…”

Section: Vitamin Ementioning

confidence: 99%

“…Kessopoulou et al, 1995 28 No effects (600 mg day 21 for 3 months, in vivo) Moilanen and Hovatta, 1995 29 No effects (600-1200 mg day 21 for 3 weeks, in vivo) Geva et al, 1996 30 No effects (200 mg day 21 for 3 months, in vivo) Vezina et al, 1996 35 Increased motility, morphology, viability; no effects on concentration (400 mg day 21 1 100-200 mg day 21 Se for 6 months, in vivo) Suleiman et al, 1996 36 Increased pregnancy rate, increased motility, reduced lipid peroxidation (300 mg day 21 for 6 months, in vivo) Kodama et al, 1997 37 Increased concentration, reduced DNA damage (200 mg vitamin C1200 mg vitamin E1GSH 400 mg every day for 2 months, in vivo) Hughes et al, 1998 38 Reduced DNA damage after Percoll preparation (30-60 mmol l 21 vitamin E, in vitro) Hughes et al, 1998 38 Increased DNA damage after Percoll preparation (300-600 mmol l 21 vitamin C1 30-60 mmol l 21 vitamin E, in vitro) Twigg et al, 1998 19 No effects on NADPH-induced lipid peroxidation (1 mmol l 21 , in vitro) Donnelly et al, 1999 39,40 Reduced H 2 O 2 -induced ROS production and DNA damage (40-60 mmol l 21 , in vitro) Rolf et al, 1999 31 No effects (800 mg vitamin E11000 mg vitamin C daily for 56 days, in vivo) Comhaire et al, 2000 41 Reduced ROS quantity; no effects on semen parameters (30 b-carotene1180 mg vitamin E daily for 3 months, in vivo) 38 Increased DNA damage after Percoll preparation (300-600 mmol l 21 vitamin C1 30-60 mmol l 21 vitamin E, in vitro) Verma and Kanwar, 1998 34 Preserved motility (800 mmol l 21 , in vitro) Donnelly et al, 1999 39,40 Reduced H 2 O 2 -induced ROS production and DNA damage (300-600 mmol l 21 , in vitro) Rolf et al, 1999 31 No effects (800 mg day 21 vitamin E11000 mg day 21 To be continued…”

Section: Antioxidant Studies Effectmentioning

confidence: 99%

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The role of antioxidant therapy in the treatment of male infertility: an overview

Lombardo¹,

Sansone²,

Romanelli³

et al. 2011

Asian J Androl

100

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In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.

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“…Three hundred milligrams of Vitamin E (the amount found in approximately 2.7 cups of sunflower oil) was supplemented twice daily for 3 months. There was a significant improvement in the in vitro ability of spermatozoa to bind the zona pellucida of unfertilized oocytes as compared to binding during the 3 months of placebo [81]. Vitamin E inhibits peroxidation of polyunsaturated fatty acids (PUFA), which is especially important in spermatozoa due to their high PUFA content [82].…”

Section: Resultsmentioning

confidence: 99%

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

Rabeh¹

2016

IJNFS

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Abstract:This study was performed to investigate the effect of halawa tahinia alone or in combination with ginger and cinnamon on sex hormones as well as serum antioxidant levels. Thirty Wistar adult male rat were divided into five groups, control group fed on basal diet only and test groups (n=24) divided into 4 groups as follow, group (1) fed on basal diet supplemented with halawa tahinia at the level of (15%), while the other three groups were fed on basal diet supplemented with halawa tahinia (15%) and were given orally (500 mg/kg/day) dried ginger, (500 mg/kg/day) dried cinnamon, both dried ginger and cinnamon (500 mg/kg/day) respectively for 8 weeks. The results indicated that, halawa tahinia have a high nutritive value. The obtained results revealed also that, oral administration of ginger and/ or cinnamon with halawa tahinia caused a significant (p<0.05) protective effects on testes due to increasing the levels of serum total testosterones, follicular stimulating hormone (FSH) and luteinizing hormone (LH) also increasing serum total antioxidants capacity (TAC) levels with decreasing malondialdehyde (MDA) level as well as have no deleterious effects on liver functions as compared to control group. Moreover, both ginger and cinnamon administration has a synergistic effect on infertility due to their antioxidant properties. In conclusion: These results provide scientific evidence to substantiate the traditional use of cinnamon and ginger as a drink as well as Halawa tahinia in improving infertility in male rats which might be a product for their potent antioxidant properties and androgenic activities.

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A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility

Cited by 307 publications

References 19 publications

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

The role of antioxidant therapy in the treatment of male infertility: an overview

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

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