A Double-Blind, Sham-Controlled Pilot Trial of Pre-Supplementary Motor Area (Pre-SMA) 1 Hz rTMS to Treat Essential Tremor

Badran, Bashar W.; Glusman, Chloe E.; Austelle, Chris W.; Jenkins, Shonna; DeVries, William H.; Galbraith, V. H.; Thomas, Tiffani; Adams, Thomas G.; George, Mark S.; Revuelta, Gonzalo J.

doi:10.1016/j.brs.2016.08.003

Cited by 25 publications

(22 citation statements)

References 9 publications

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“…A current subgroup analysis revealed comparable significant therapeutic effects across two different times of testing (posttest: ≤ 1 day and retention test: > 1 day) after stimulation. We included and analyzed seven comparisons from two studies [ 23 , 29 ]. A mean interval between the baseline and retention test in this meta-analysis was 39.8 days (range: 7–84 days).…”

Section: Discussionmentioning

confidence: 99%

Does non-invasive brain stimulation reduce essential tremor? A systematic review and meta-analysis

Kang

Cauraugh

2017

PLoS ONE

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Essential tremor (ET) is the most common age-related disease leading to abnormal tremulous behaviors in the upper and lower extremities. Non-invasive brain stimulation (NIBS) may be an effective ET therapy by modulating the oscillating network of the brain. The current systematic review and meta-analysis examined the effects of NIBS interventions on tremor symptoms in ET patients. Our comprehensive search identified eight studies that used 1 Hz of rTMS, cTBS, or ctDCS protocols. Twenty total comparisons from the eight qualified studies were statistically synthesized, and the meta-analytic findings revealed that NIBS techniques reduced tremulous behaviors in individuals with ET. Moreover, the four moderator variable analyses demonstrated that the positive therapeutic effects of NIBS appeared across the following subgroups: (a) tremor assessment (clinical test vs. quantitative tremor assessment), (b) stimulation site (cerebellum vs. motor cortex), (c) session number (single session vs. multiple sessions), and (d) sustained positive treatment effect (posttest vs. retention test). This comprehensive systematic review and meta-analysis provided evidence that support positive treatment effects of NIBS techniques on ET motor therapy.

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Section: Discussionmentioning

confidence: 99%

Does non-invasive brain stimulation reduce essential tremor? A systematic review and meta-analysis

Kang

Cauraugh

2017

PLoS ONE

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“…Inhibitory low frequency rTMS was pursued in one study for 15 stimulation days and the investigators chose the pre-SMA as the target. The study found that compared to sham stimulation, there were sustained benefits at 8-week follow-up in the active stimulation group (40).…”

Section: Therapeutic Use Of Rtmsmentioning

confidence: 91%

Transcranial Magnetic Stimulation in Tremor Syndromes: Pathophysiologic Insights and Therapeutic Role

et al. 2021

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Transcranial magnetic stimulation (TMS) is a painless, non-invasive, and established brain stimulation technique to investigate human brain function. Over the last three decades, TMS has shed insight into the pathophysiology of many neurological disorders. Tremor is an involuntary, rhythmic oscillatory movement disorder commonly related to pathological oscillations propagated via the cerebello-thalamo-cortical pathway. Although tremor is the most common movement disorder and recent imaging studies have enhanced our understanding of the critical pathogenic networks, the underlying pathophysiology of different tremor syndromes is complex and still not fully understood. TMS has been used as a tool to further our understanding of tremor pathophysiology. In addition, repetitive TMS (rTMS) that can modulate brain functions through plasticity effects has been targeted to the tremor network to gain potential therapeutic benefits. However, evidence is available for only a few studies that included small patient samples with limited clinical follow-up. This review aims to discuss the role of TMS in advancing the pathophysiological understanding as well as emerging applications of rTMS for treating individual tremor syndromes. The review will focus on essential tremor, Parkinson's disease tremor, dystonic tremor syndrome, orthostatic tremor, and functional tremor.

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“…A single session of cerebellar cTBS did not show modification of tremor frequency, smoothness of reaching movements, or clinical rating of tremor . Other targets have been stimulated in further studies, such as M1, through a single session of cTBS, and pre‐SMA, with 15 daily sessions of 1 Hz rTMS . The results on clinical outcomes were null, but cTBS on M1 could improve tremor measured with an accelerometer .…”

Section: The Use Of Rtms For the Treatment Of MDmentioning

confidence: 93%

The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

et al. 2019

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A BS TRACT: Background: Transcranial magnetic stimulation is a safe and painless non-invasive brain stimulation technique that has been largely used in the past 30 years to explore cortical function in healthy participants and, inter alia, the pathophysiology of movement disorders. During the years, its use has evolved from primarily research purposes to treatment of a large variety of neurological and psychiatric diseases. In this article, we illustrate the basic principles on which the therapeutic use of transcranial magnetic stimulation is based and review the clinical trials that have been performed in patients with movement disorders.

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A Double-Blind, Sham-Controlled Pilot Trial of Pre-Supplementary Motor Area (Pre-SMA) 1 Hz rTMS to Treat Essential Tremor

Cited by 25 publications

References 9 publications

Does non-invasive brain stimulation reduce essential tremor? A systematic review and meta-analysis

Does non-invasive brain stimulation reduce essential tremor? A systematic review and meta-analysis

Transcranial Magnetic Stimulation in Tremor Syndromes: Pathophysiologic Insights and Therapeutic Role

The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

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