A double-blind, side-by-side comparison study of low fluence long pulse dye laser to coolant treatment for wrinkling of the cheeks

Rostan, Elizabeth F.; Bowes, Leyda E.; Iyer, Srinivasan; Fitzpatrick, Richard

doi:10.1080/147641701753414933

Cited by 85 publications

(45 citation statements)

References 17 publications

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“…Nevertheless, from six randomized controlled trials and four non-randomized controlled trials it seems that non-ablative skin rejuvenation induces a mild to moderate improvement of rhytides lasting up to 6 months after end treatment [4,9,10,21,[28][29][30][31][32][33]. However, blinded evaluations as well as statistical analysis were not performed in all studies.…”

Section: Discussionmentioning

confidence: 99%

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

et al. 2006

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Background and Objective: To compare efficacy and side effects of CO 2 laser resurfacing and intense pulsed light (IPL) rejuvenation for treatment of perioral rhytides. Methods: Twenty-seven female subjects with perioral rhytides (class I-III) were randomly treated with either CO 2 laser or IPL (three monthly treatments). Efficacy was evaluated by patient self-assessments and blinded photographs up to 12 months postoperatively. Side effects were assessed clinically. Non-invasive measurements included: trans epidermal water loss (TEWL), skin reflectance, skin elasticity, and ultrasound. Results: CO 2 laser resurfacing resulted in higher degrees of patient satisfaction and clinical rhytide reduction compared to IPL rejuvenation up to 12 months postoperatively (patient evaluations, P < 0.05) (observer evaluations, P < 0.008). Laser-induced side effects included erythema, dyspigmentation, and milia whereas no side effects were observed after IPL rejuvenation. Non-invasive measurements showed a significant higher reduction of the subepidermal low-echogenic band in CO 2 laser treated areas versus IPL treated areas (12 months postoperatively, P < 0.001). Skin elasticity (expressed as Young's modulus) increased in both groups (P ¼ ns). One month postoperatively a significant increase in TEWL values (P < 0.009) and skin redness% (P < 0.02) was found in CO 2 laser treated patients versus IPL treated patients. No significant differences were seen in skin pigmentation% during the observation period. Conclusion: CO 2 laser resurfacing induces a significantly higher degree of clinical rhytide reduction followed by considerably more side effects compared to IPL rejuvenation in a homogeneous group of patients.

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Section: Discussionmentioning

confidence: 99%

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

et al. 2006

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“…Low energy pulsed-dye lasers (e.g., ''Nlite'') as well as long-pulse pulsed-dye lasers (e.g., pulse durations of 10-40 milliseconds) have also been studied. In one investigation [59] involving a long-pulse 595 nm device, 3 mm skin biopsies were obtained before treatment, 4-6 weeks after a series of four treatments, and 3 months after the treatment cycle. Hematoxylin and eosin (H&E) staining as well as type I procollagen staining was performed to assess deposition of collagen and the activity of dermal fibroblasts.…”

Section: Pulsed-dye Lasermentioning

confidence: 99%

Nonablative laser and light treatments: Histology and tissue effects—A Review

et al. 2003

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(a) Thermal injury to the dermis in association with epidermal cooling most likely affects the dermal vasculature, which initiates a cascade of inflammatory events that includes fibroblastic proliferation and apparent up-regulation of collagen expression; (b) There is no indication that nonablative treatments are harmful or able to induce skin cancer; (c) It is possible that the horizontally distributed collagen reported after nonablative treatments is a "microscar," an enlarged Grenz sone associated with repetitive photo-induced trauma; (d) Further research is needed to elucidate the biophysical mechanisms underlying nonablative treatment, as well as to distinguish the utility of different wavelengths on epidermal and dermal improvement.

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“…Histologic evaluation demonstrated an increase in activated fibroblasts with positive pro-collagen staining on the LPDL treated cheek [11].…”

Section: Lasers That Target Discrete Chromophoresmentioning

confidence: 98%

Update on non‐ablative light therapy for rejuvenation: A review

2003

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Non-ablative technologies are playing an increasing role in the management of photoaging. Newer radiofrequency technologies have added to this therapeutic armamentarium. Shorter wavelength technologies are more effective in targeting pilosebaceous vascular and pigmentary alterations while longer wavelength technologies are most effective in wrinkle reduction mediated through dermal remodeling. An overview of the various technologies available to the practicing laser surgeon are outlined in the present review.

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A double-blind, side-by-side comparison study of low fluence long pulse dye laser to coolant treatment for wrinkling of the cheeks

Abstract: The 595 nm LPDL may be used in the treatment of moderate to severe wrinkles. A mild improvement may be expected with minimal to no side effects.

Cited by 85 publications

References 17 publications

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

Nonablative laser and light treatments: Histology and tissue effects—A Review

Update on non‐ablative light therapy for rejuvenation: A review

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