A Double Blind Study of the Effect of Phenobarbitone on Neonatal Hyperbilirubinaemia and Frequency of Exchange Transfusion

Signer, M. Vest. E.; Weisser, K; Ólafsson, Andri

doi:10.1111/j.1651-2227.1970.tb17705.x

Cited by 20 publications

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“…Several studies on the effect of phenobarbital on the hyperbilirubinemia of non-hemolytic disease of newborn infants have been conducted, which have shown that phenobarbital decreases the rate of blood exchange transfusion 9 , 11 – 13 , 16 – 21 ; on the other hand, some studies have reported that phenobarbital has no effect on the TSB level in newborns with non-hemolytic disease and thus has no effect on the rate of blood exchange transfusion. 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

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Phenobarbital and Phototherapy Combination Enhances Decline of Total Serum Bilirubin and May Decrease the Need for Blood Exchange Transfusion in Newborns with Isoimmune Hemolytic Disease

Kaabneh

Salama

Shakkoury

et al. 2015

Clin Med Insights Pediatr

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OBJECTIVEThe objective of this study was to evaluate the effect of phenobarbital and phototherapy combination on the total serum bilirubin of the newborn infants with isoimmune hemolytic disease (IHD) and its impact on blood exchange transfusion rates.PATIENTS AND METHODThis single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with IHD were divided randomly into two groups: (1) the phenobarbital plus phototherapy group (n = 103), and (2) the phototherapy-only group (n = 97). Infants in group 1 received an oral dose of 2.5 mg/kg phenobarbital every 12 hours for 3 days in addition to phototherapy. The total serum bilirubin was observed.RESULTSOf the total 200 included newborn infants, 186 infants completed the study: 97 infants were included in group 1 and 89 infants in group 2. The difference between the mean total serum bilirubin levels at 24, 48, and 72 hours after starting the trial was clinically and statistically significant at P < 0.05. The differences between the two groups were also statistically significant at P < 0.05. Of the total 186 who completed the study, only 22 underwent blood exchange transfusion [7 from group 1, and 15 from group 2 (P = 0.0478)].CONCLUSIONIn a limited-resources setting, phenobarbital in combination with phototherapy may be helpful to newborn infants with IHD, as it results in a faster decline in total serum bilirubin, thus decreasing the need for blood exchange transfusion than phototherapy alone.

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Section: Discussionmentioning

confidence: 99%

“…There are several studies that evaluated the effect of phenobarbital prophylaxis given either to the mother of suspected ABO or Rh incompatibility fetus just before delivery, or to the newborn immediately after birth. 13 – 15 , 24 – 28 …”

Section: Discussionmentioning

confidence: 99%