A double-layered gastric floating tablet for zero-order controlled release of dihydromyricetin: Design, development, and in vitro/in vivo evaluation

Shi, Houyin; Li, Sifang; Zhang, Hao; Zhang, Dan; Wu, Ailing; Zhang, Chun; Li, Chunhong; Fu, Xiujuan; Chen, Siwei; Shi, Jiaoyue; Tian, Ye; Wang, Sihan; Wang, Yu; Líu, Hao

doi:10.1016/j.ijpharm.2023.122929

Cited by 10 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data were analyzed using two-tailed Student’s t -tests for two groups and one-way ANOVA for multiple groups [ 46 ]. The data were reported as mean ± SD, unless otherwise indicated.…”

Section: Methodsmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Lactoferrin-Modified Liposomal Etomidate with Enhanced Brain-Targeting Effect for General Anesthesia

Wu,

Shi,

Yang

et al. 2024

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Etomidate is a general anesthetic that has shown good hemodynamic stability without significant cardiovascular or respiratory depression. Despite several kinds of dosage forms having been reported for this drug, formulation types are very limited in clinical practice, and brain-targeted formulations for this central nervous system (CNS) drug have been rarely reported. Moreover, studies on the biocompatibility, toxicity, and anesthetic effects of the etomidate preparations in vivo were inadequate. The present study was to develop lactoferrin-modified liposomal etomidate (Eto-lip-LF) for enhanced drug distribution in the brain and improved anesthetic effects. Eto-lip-LF had good stability for storage and hemocompatibility for intravenous injection. Compared with the non-lactoferrin-containing liposomes, the lactoferrin-modified liposomes had notably enhanced brain-targeting ability in vivo, which was probably realized by the binding of transferrin with the transferrin and lactoferrin receptors highly distributed in the brain. Eto-lip-LF had a therapeutic index of about 25.3, higher than that of many other general anesthetics. Moreover, compared with the commercial etomidate emulsion, Eto-lip-LF could better achieve rapid onset of general anesthesia and rapid recovery from anesthesia, probably due to the enhanced drug delivery to the brain. The above results demonstrated the potential of this lactoferrin-modified liposomal etomidate to become an alternative preparation for clinical general anesthesia.

show abstract

“…The data were analyzed using two-tailed Student’s t -tests for two groups and one-way ANOVA for multiple groups [ 46 ]. The data were reported as mean ± SD, unless otherwise indicated.…”

Section: Methodsmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Lactoferrin-Modified Liposomal Etomidate with Enhanced Brain-Targeting Effect for General Anesthesia

Wu,

Shi,

Yang

et al. 2024

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Generally, many natural flavonoids have the disadvantages of poor water solubility, susceptibility to oxidation, and low bioavailability [187][188][189][190]. These problems can be solved by some methods, such as prodrug design [191], formulation optimization [192], and nano-drug delivery systems, including liposomes [193,194], nanoparticles [195,196], phytosomes [197], dendrimers [198], polymer-drug conjugates [199], and microparticles [200]. Similarly, numerous attempts have been made to increase tectorigenin's water solubility, stability, and bioavailability by employing diverse delivery strategies.…”

Section: Delivery Strategy Of Tectorigeninmentioning

confidence: 99%

Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics

Rong,

Fu,

Han

et al. 2023

Molecules

View full text Add to dashboard Cite

Tectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests that tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, antioxidative, antimicrobial, cardioprotective, and neuroprotective. These pharmacological properties provide the basis for the treatment of many kinds of illnesses, including several types of cancer, diabetes, hepatic fibrosis, osteoarthritis, Alzheimer’s disease, etc. The purpose of this paper is to provide a comprehensive summary and review of the sources, extraction and synthesis, pharmacological effects, toxicity, pharmacokinetics, and delivery strategy aspects of tectorigenin. Tectorigenin may exert certain cytotoxicity, which is related to the administration time and concentration. Pharmacokinetic studies have demonstrated that the main metabolic pathways in rats for tectorigenin are glucuronidation, sulfation, demethylation and methoxylation, but that it exhibits poor bioavailability. From our perspective, further research on tectorigenin should cover: exploring the pharmacological targets and mechanisms of action; finding an appropriate concentration to balance pharmacological effects and toxicity; attempting diversified delivery strategies to improve the bioavailability; and structural modification to obtain tectorigenin derivatives with higher pharmacological activity.

show abstract

Development of the novel formulations of perospirone for the treatment of schizophrenia

Zhang,

Ke,

et al. 2024

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

A double-layered gastric floating tablet for zero-order controlled release of dihydromyricetin: Design, development, and in vitro/in vivo evaluation

Cited by 10 publications

References 42 publications

In Vitro and In Vivo Evaluation of Lactoferrin-Modified Liposomal Etomidate with Enhanced Brain-Targeting Effect for General Anesthesia

In Vitro and In Vivo Evaluation of Lactoferrin-Modified Liposomal Etomidate with Enhanced Brain-Targeting Effect for General Anesthesia

Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics

Development of the novel formulations of perospirone for the treatment of schizophrenia

Contact Info

Product

Resources

About