A “double-locked” probe for the detection of hydrogen sulfide in a viscous system

Kong, Fanming; Wang, Xiaoxiu; Bai, Jundong; Xiao, Liquan; Yang, Chao; Li, Ying; Xu, Kehau; Tang, Bo

doi:10.1039/d1cc01819a

Cited by 34 publications

(12 citation statements)

References 46 publications

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“…Fluorescent probes employing a "double-lock" sequential activation strategy have higher specificity and accuracy compared to single-site release fluorescence (Liu et al, 2019). In 2021, a "double-locked" fluorescent probe 7 for monitoring H 2 S in high-viscosity systems was obtained by Kong and coworkers (Kong et al, 2021). In high-viscosity environments (the first "key"), 2,4-dinitrobenzenesulfonate group (the second "key") in probe 7 was recognized with H 2 S, and the fluorescence signal around 630 nm was enhanced 50-fold.…”

Section: Parkinson's Disease Imagingmentioning

confidence: 99%

H2S-based fluorescent imaging for pathophysiological processes

Jia

Zhang²,

Hou³

et al. 2023

Front. Chem.

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Hydrogen sulfide (H2S), as an important endogenous signaling molecule, plays a vital role in many physiological processes. The abnormal behaviors of hydrogen sulfide in organisms may lead to various pathophysiological processes. Monitoring the changes in hydrogen sulfide is helpful for pre-warning and treating these pathophysiological processes. Fluorescence imaging techniques can be used to observe changes in the concentration of analytes in organisms in real-time. Therefore, employing fluorescent probes imaging to investigate the behaviors of hydrogen sulfide in pathophysiological processes is vital. This paper reviews the design strategy and sensing mechanisms of hydrogen sulfide-based fluorescent probes, focusing on imaging applications in various pathophysiological processes, including neurodegenerative diseases, inflammation, apoptosis, oxidative stress, organ injury, and diabetes. This review not only demonstrates the specific value of hydrogen sulfide fluorescent probes in preclinical studies but also illuminates the potential application in clinical diagnostics.

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Section: Parkinson's Disease Imagingmentioning

confidence: 99%

H2S-based fluorescent imaging for pathophysiological processes

Jia

Zhang²,

Hou³

et al. 2023

Front. Chem.

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“…In 2021, Kong et al presented a dual-locked probe (DCO-H 2 SÀ V) based on dicyanoisophorone (DCO) platform functionalized with two 2, 4-dinitrobenzenesulfonate groups for the detection of H 2 S in high viscosity systems (Figure 28). [53] Probe DCO-H 2 SÀ V had a very low intrinsic fluorescence because of the conbined quenching effect from two dinitrobenzenesulfonate groups and the rotation of double carbon bond between dicyanoisophorone and dioxynaphthalene. With the dual activation of H 2 S and high viscosity environment, probe DCO-H 2 SÀ V can be converted into the typical DÀ A structure (DCON), accompanied by strong red fluorescence emission.…”

Section: Viscosity -Assisted Activatable Dual-target Fluorescent Probesmentioning

confidence: 99%

Recent Advances in Dual‐target‐activated Fluorescent Probes for Biosensing and Bioimaging

Han

Xiong

Ren

et al. 2022

Chemistry An Asian Journal

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Fluorescent probes have been powerful tools for visualizing and quantifying multiple dynamic processes in living cells. However, the currently developed probes are often constructed by conjugation a fluorophore with a recognition moiety and given signal‐output after triggering with one singly target interest. Compared with the single‐target‐activated fluorescent probes mentioned above, the dual‐target‐activated ones, triggering with one target under stimulus (such as photoirradiation, microenvironment) or another targets, have the advantages of advoiding nonspecific activation and “false positive” results in complicated environments. In recent years, many dual‐target‐activated fluorescent probes have been developed to detect various biologically relevant species. In view of the importance of a comprehensive understanding of dual‐target‐ activated fluorescent probes, a thorough summary of this topic is urgently needed. However, no comprehensive and critical review on dual target activated fluorescent probes has been published recently. In this review, we focus on the dual‐target‐activated fluorescent probes and briefly outline their types and current state of development. In each type, the chemical structure, proposed responsive mechanism and application of probes are highlighted. At last, the challenges and prospective opportunities of every type were proposed.

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“…17,18 Additionally, change in intracellular viscosity is closely related to Parkinson's disease. 19 Because cysteine has a direct effect on intracellular viscosity, the simultaneous detection of cysteine and viscosity requires supplementary investigation for advanced research in the medical and biological fields.…”

Section: Introductionmentioning

confidence: 99%

A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells

et al. 2023

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A “double-locked” probe for the detection of hydrogen sulfide in a viscous system

Abstract: A novel“double-locked” probe, DCO-H2S-V, has been prepared for detecting hydrogen sulfide in high viscous system. Experiments demonstrated that only when H2S and high viscosity coexist in the cell, can the...

Cited by 34 publications

References 46 publications

H2S-based fluorescent imaging for pathophysiological processes

H2S-based fluorescent imaging for pathophysiological processes

Recent Advances in Dual‐target‐activated Fluorescent Probes for Biosensing and Bioimaging

A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells

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