A doxycycline loaded, controlled-release, biodegradable fiber for the treatment of aortic aneurysms

Yamawaki-Ogata, Aika; Hashizume, Ryotaro; Satake, Makoto; Kaneko, Hiroaki; Mizutani, S; Moritan, Toshiyuki; Ueda, Yuichi

doi:10.1016/j.biomaterials.2010.08.069

Cited by 38 publications

(35 citation statements)

References 60 publications

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“…For example, treatment with angiotensin converting enzyme inhibitor and statins reduced AAA rupture in a case-control study [36,37]. In addition, doxycycline treatment decreased the aneurismal expansion rate in an experimental mouse model [38] and in a randomized double-blinded clinical trial [39]. In addition, nonsteroidal antiinflammatory drugs decrease AAA expansion rate in a case control study [40] and inhibition of c-Jun N-terminal kinase regresses AAA in CaCl 2 -treated mice [41].…”

Section: Discussionmentioning

confidence: 99%

“…Although doxycycline provided significant beneficial effects in avoiding AAA formation in a variety of animal models and humans [9,20,24,38,45,56,57,59,60], a systematic review of the literature (six trials and two cohort studied) showed no conclusive benefit with doxycycline [23]. However, Dodd and Spence (2011) postulated that it was due to poor methodological quality with small numbers (just 255 subjects analyzed), lack of adjustment for confounding variables, short-term doxycycline exposure, and a lack of long-term follow up [23].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms

Mata¹,

Tefé‐Silva²,

Floriano³

et al. 2015

Cardiovascular Pathology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms

Mata¹,

Tefé‐Silva²,

Floriano³

et al. 2015

Cardiovascular Pathology

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“…2 Meanwhile, our previous studies reported a sustained drug delivery system (DDS) using electrospinning biodegradable fiber with various types of drugs. 12,13,31 Sustained drug release can be adjusted by modification in the polymer degradation and can contribute to minimizing systemic influences and adverse side effects, while maximizing the local effects. Furthermore, the electrospinning process provides engineering scaffolds with nano-to microscale topography and high porosity similar to the natural extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Osteogenic Induction of Bone Marrow-Derived Stromal Cells on Simvastatin-Releasing, Biodegradable, Nano- to Microscale Fiber Scaffolds

et al. 2011

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Tissue engineering is an effective approach for the treatment of bone defects. Statins have been demonstrated to promote osteoblastic differentiation of bone marrow-derived stromal cells (BMSCs). Electrospun biodegradable fibers have also shown applicability to drug delivery in the form of bone tissue engineered scaffolds with nano- to microscale topography and high porosity similar to the natural extracellular matrix (ECM). The aim of this study was to investigate the feasibility of a simvastatin-releasing, biodegradable, nano- to microscale fiber scaffold (SRBFS) for bone tissue engineering with BMSCs. Simvastatin was released from SRBFS slowly. BMSCs were observed to spread actively and rigidly adhere to SRBFS. BMSCs on SRBFS showed an increase in alkaline phosphatase activity 2 weeks after cell culture. Furthermore, osteoclastogenesis was suppressed by SRBFS in vitro. The new bone formation and mineralization in the SRBFS group were significantly better than in the biodegradable fiber scaffold (BFS) without simvastatin 12 weeks after implantation of the cell-scaffold construct into an ectopic site on the murine back. These results suggest that SRBFS promoted osteoblastic differentiation of BMSCs in vitro and in vivo, and demonstrate feasibility as a bone engineering scaffold.

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“…Numbers of men with AAA (%) and total number of men in each quintile are shown. of extracellular matrix and reduced expression of matrix metalloproteinases (24). IGF1 stimulates collagen synthesis (25) and facilitates wound-healing (26), mechanisms that could protect against the development of AAA.…”

Section: Discussionmentioning

confidence: 99%

Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men

Yeap

Chubb

McCaul

et al. 2012

European Journal of Endocrinology

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Objective: Abdominal aortic aneurysm (AAA) is most prevalent in older men. GH secretion declines with age resulting in reduced IGF1 levels. IGF1 and its binding proteins (IGFBPs) are expressed in vasculature, and lower IGF1 levels have been associated with cardiovascular risk factors and disease. However, the relationship of the IGF1 system with aortic dilation and AAA is unclear. We tested the hypothesis that circulating IGF1 and IGFBPs are associated with AAA and aortic diameter in older men. Design: A cross-sectional analysis involving 3981 community-dwelling men aged 70-89 years was performed. Methods: Abdominal aortic diameter was measured by ultrasound. Plasma total IGF1, IGFBP1 and IGFBP3 were measured by immunoassays. Results: After adjustment for age, body mass index, waist:hip ratio, smoking, hypertension, dyslipidemia, diabetes, coronary heart disease and serum creatinine, a higher IGF1 level was associated with AAA (odds ratio (OR)/1 S.D. increase 1.18, 95% confidence interval (CI) 1.05-1.33, PZ0.006), as was the ratio of IGF1/IGFBP3 (ORZ1.22, 95% CI 1.10-1.35, P!0.001). Highest IGF1 concentrations compared with lowest quintile were significantly associated with AAA (quintile (Q) 5 vs Q1: ORZ1.80, 95% CI 1.20-2.70, PZ0.004) as were IGF1/IGFBP3 ratios (Q5 vs Q1: ORZ2.52, 95% CI 1.59-4.02, P!0.001). IGF1 and IGFBP1 were independently associated with aortic diameter (bZ0.200, 95% CI 0.043-0.357, PZ0.012 and bZ0.274, 95% CI 0.098-0.449, PZ0.002 respectively). Conclusions: In older men, higher IGF1 and an increased ratio of IGF1/IGFBP3 are associated with AAA, while IGFBP1 is independently associated with increased aortic diameter. Components of the IGF1 system may contribute to, or be a marker for, aortic dilation in ageing men.

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A doxycycline loaded, controlled-release, biodegradable fiber for the treatment of aortic aneurysms

Cited by 38 publications

References 60 publications

Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms

Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms

Osteogenic Induction of Bone Marrow-Derived Stromal Cells on Simvastatin-Releasing, Biodegradable, Nano- to Microscale Fiber Scaffolds

Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men

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