As a result of the conducted phytochemical studies of sesquiterpene lactones of some plants of the genus Artemisia, Centaurea, Jurinea, and Handelia of the Asteraceae family and the study of biostimulating, mutagenic, and insecticidal activity of isolated individual lactones and total preparations in rice farming, cotton growing, as well as against termites, the following biologically active environmentally safe natural remedies have been created: an effective stimulant that, when soaking rice seeds, increases the yield 12-14 quintals per hectare as an average, promising mutant lines and two new cotton varieties have been created on the basis of the polar lactone sum (PLS), and anti-termite sesquiterpene lactones have been isolated, which at low concentrations destroy termites by 90-96%.