A drift on liposomes to proliposomes: recent advances and promising approaches

Dhiman, Neha; Sarvaiya, Jayrajsinh; Mohindroo, Poorti

doi:10.1080/08982104.2021.2019762

Cited by 17 publications

(8 citation statements)

References 136 publications

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“…The mixture was transferred into a 250 mL round flask to completely remove the chloroform, using a R-3 rotary vacuum evaporator (rotate at 100 rpm) (Buchi Laboratory Equipment Trading Co., Ltd., Shanghai, China) at 37 • C. After the thin lipid film was formed, 100 mL of distilled water was added to hydrate with the lipid film by rotating for 30 min at 200 rpm in a 37 • C water-bath. After that, the solution was treated with ultrasound (JY92-IIN, biotechnology Co., Ltd., Ningbo, China) at 400 W for 4 min with 3 s pulse-on and 3 s pulse-off in an ice-bath to transform liposomes from MLV to UV, and then successively filtered through 0.45 µm and 0.22 µm water microfiltration membranes to obtain MRPL suspension [12,18]. The suspension was centrifugated at 45,000 rpm for 30 min at 4 • C using a Sorvall MTX 150 ultracentrifuge (Thermo Fisher Scientific Inc., Waltham, MA, USA) to collected MRPL precipitate and to remove the unencapsulated MRPs; the encapsulation rate of MRPs was 49% ± 2.6%.…”

Section: Preparation Of Mrplmentioning

confidence: 99%

Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

Peng

Zhu

Lai

et al. 2023

Foods

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Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitro simulated gastrointestinal digestion stability revealed that, compared with free MRPs, liposomes embedding significantly enhanced the stability of MRPs when exposed to adverse environmental conditions. Furthermore, anticancer assay suggested that MRPL exhibited a stronger inhibitory effect on MKN-28 cells by damaging the integrity of cells, with the IC50 value at 0.57 mg/mL. Overall, MRPLs possess stronger stability in external environment and in vitro simulated digestion with greater anticancer activity, indicating that MRPLs have the potential for promising application in the functional foods and pharmaceutical industries.

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Section: Preparation Of Mrplmentioning

confidence: 99%

Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

Peng

Zhu

Lai

et al. 2023

Foods

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“…In addition, the orally administered DHA suspension group exhibited rapid absorption with a T max of 0.45 h, whereas the PEG-LPs-DHA group and SER-LPs-DHA group exhibited a similar pharmacokinetic behavior but prolonged T max of 0.95 h and 1.15 h. The prolonged action time of DHA in the PEG-LPs-DHA group and SER-LPs-DHA group could be derived from the delayed release from the liposomes, as one might predict based on findings of the same in the above in vitro release study. 63 Similarly, the MRT 0-24 (5.60 h and 6.44 h) of the PEG-LPs-DHA group and SER-LPs-DHA group were delayed to a large extent compared with that of the DHA suspension group (2.93 h), which suggested that the liposome formulation could decrease the elimination rates of DHA. 64 , 65 …”

Section: Resultsmentioning

confidence: 94%

2-Monoacylglycerol Mimetic Liposomes to Promote Intestinal Lymphatic Transport for Improving Oral Bioavailability of Dihydroartemisinin

Zheng,

Pan,

Shi

et al. 2024

IJN

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“…One caveat of our study is that we have yet to determine which factor(s) cause the increasing size and charges of liposome‐EV‐KRAS when compared with liposomes alone. The factor(s) could be from EV‐KRAS complex derived or unidentified factors (Sani et al., 2022 , Sheikholeslami et al., 2022 ) including aggregation (Dhiman et al., 2022 ). Future work is needed to identify the involved factor(s).…”

Section: Discussionmentioning

confidence: 99%

An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth

Sriwastva

Teng

et al. 2023

J of Extracellular Vesicle

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Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or different biological effect from that identified in EV‐producing cells has never been demonstrated. Here, as a proof‐of‐concept, we demonstrate that EV‐G12D‐mutant KRAS serves as a leader that forms a protein complex and promotes lung inflammation and tumour growth via the Fn1/IL‐17A/FGF21 axis. Mechanistically, in contrast to cytosol derived G12D‐mutant KRAS complex from EVs‐producing cells, EV‐G12D‐mutant KRAS interacts with a group of extracellular vesicular factors via fibronectin‐1 (Fn1), which drives the activation of the IL‐17A/FGF21 inflammation pathway in EV recipient cells. We show that: (i), depletion of EV‐Fn1 leads to a reduction of a number of inflammatory cytokines including IL‐17A; (ii) induction of IL‐17A promotes lung inflammation, which in turn leads to IL‐17A mediated induction of FGF21 in the lung; and (iii) EV‐G12D‐mutant KRAS complex mediated lung inflammation is abrogated in IL‐17 receptor KO mice. These findings establish a new concept in EV function with potential implications for novel therapeutic interventions in EV‐mediated disease processes.

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A drift on liposomes to proliposomes: recent advances and promising approaches

Cited by 17 publications

References 136 publications

Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

2-Monoacylglycerol Mimetic Liposomes to Promote Intestinal Lymphatic Transport for Improving Oral Bioavailability of Dihydroartemisinin

An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth

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