In this study, the shoreline and lake surface area changes of Lake Manyas were analysed by using Geographical Information Systems (GIS) and Remote Sensing (RS) techniques for long term (1980-2020) and annual (2022) with DSAS tool. In the study, a formula was created using NDWI, MDWI, WRI water indices and NDVI, RVI, NDMI, GCI vegetation indices over Landsat satellite images of 1980, 1985, 1990, 1995, 2000, 2000, 2005, 2005, 2010, 2015, 2020 and all months of 2022, and shoreline extraction was performed. Then, shoreline and lake surface area change were analysed over different periods with NSM, EPR, SCE, LRR statistics in DSAS tool. According to the results of the analyses, the average shoreline changes between 1980 and 2020 was 139 m according to NSM statistics, 3,5 m/year according to EPR, 243.1 m according to SCE and 3.4 m/year according to LRR. While the shoreline extended a maximum of 1599 m, the minimum value was -403 m. From 1980 to 2020, 5.85 km2 coastal accumulation, 1.03 km2 coastal erosion and 146.5 km2 permanent lake surface area data were determined on the surface area and shores of Lake Manyas. According to the monthly data of Lake Manyas for 2022, the shoreline is advancing by 18 m on average. Due to the natural dynamic process and the productive structure of the wetland system, the lake surface area reaches its widest size in April with 149.01 km2 and its narrowest area is 146.05 km2 in August. On the southern shores of Lake Manyas, reedbed development and coastal accumulation are intensely experienced with the progression of the Manyas Stream delta, while coastal erosion is observed on the northern shores.