A dual-channel chemodosimetric sensor for discrimination between hypochlorite and nerve-agent mimic DCP: application on human breast cancer cells

Abstract

A styryl bridge containing triphenylamine-thioimidazole hydrazine-based dual-analytes responsive fluorescent sensor was designed and synthesized for detection of nerve gas simulant diethyl chlorophosphate and hypochlorite for the first time. The hypochlorite...

3‐Pyrrolyl BODIPY Based Schiff Base Fluorophores: A Selective Chemodosimetric and Optical Sensor for Diethyl Chlorophosphate

“…The limit of detection (LOD) and limit of quantification (LOQ) of DCP interaction with 2 calculated [32] from fluorescence data were estimated to be 1.28 � 0.3 nM and 4.22 � 0.3 nM respectively. As a result, the lower LOD value (1.28 � 0.3 nM) indicates that the probe is more sensitive to DCP detection than previously reported probes, [33][34][35][36][37][38] whose LOD values were in the range of 3 nM-84 μM.…”

A ratiometric small-molecule fluorescent probe for the selective detection of hypochlorite by an oxidative cyclization reaction: application to commercial disinfectants and live cells

“…[19][20][21][22] Among the most commonly used recognition moieties for hypochlorite detection, 2-hydrazino benzothiazole has a few limited applications, and there are only a few reports based on this moiety where hypochlorous-acid-activated intramolecular cyclization of heterocyclic hydrazone occurred to form a new product (1,2,4-triazole). [23][24][25] Based on our research on the oxidation reaction of hypochlorite, we constructed a new yellowemitting thiophene-based ratiometric fluorescent probe, TPBN, via the Suzuki cross-coupling reaction. Initially, the yellow fluorescence was observed due to the presence of strong ICT, and after the incorporation of hypochlorite, there was a cyclization-induced weakening of the ICT process, resulting in the weak blue-emitting 1,2,4-triazole product (TPBN-P).…”

Visual and ratiometric fluorescent probe via an intramolecular charge transfer for detection of a nerve agent simulant in solutions and in the gas phase

“…Additionally, different chemosensing approaches for DCP detection have been established so far, such as phosphorylation of -OH functional groups, conversion of oxime to benzisoxazole, the addition of a phosphoryl group to an amine group or oxime group, etc. [16][17][18][19][20] In 2017, Mondal's group reported a probe for the first time where the nitrogen atom of benzimidazole takes part in a a Molecular Sensor and Supramolecular Chemistry Laboratory, Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711 103, India. E-mail: akmahapatra@chem.iiests.ac.in; Tel: +91-9434508013 b Division of Molecular Medicine, Bose Institute, P 1/12, CIT Scheme VIIM, nucleophilic attack on the electrophilic center of DCP.…”

“…Additionally, different chemosensing approaches for DCP detection have been established so far, such as phosphorylation of –OH functional groups, conversion of oxime to benzisoxazole, the addition of a phosphoryl group to an amine group or oxime group, etc . 16–20 In 2017, Mondal's group reported a probe for the first time where the nitrogen atom of benzimidazole takes part in a nucleophilic attack on the electrophilic center of DCP. 21 Later, Cheng et al developed a compound where the pyridinyl nitrogen is involved in nucleophilic attack.…”