A dual-functional chemosensor for fluorescent on-off and ratiometric detection of Cu2+ and Hg2+ and its application in cell imaging

Zeng, Shuang; Li, Shijie; Sun, Xuping; Liu, Tingting; Zhang, Xing

doi:10.1016/j.dyepig.2019.107642

Cited by 40 publications

(11 citation statements)

References 49 publications

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“…Importantly, a new absorption can be observed at 1121 cm −1 when CPBI 2 interacts with Cu 2+ . It is consistent with the results in the literature [ 16 , 60 , 61 , 62 ]. In addition, the results of SEM further demonstrate that the original nanoparticle structure of CPBI 2 ( Figure 7 d) has aggregated into a massive flaky structure ( Figure 7 c) after the interaction of CPBI 2 with Cu 2+ .…”

Section: Resultssupporting

confidence: 93%

“…When In 1 and In 2 are in the state (0, 1), the output signal is on (1) ( Figure 9 e). Therefore, the IMPLICATION logic gate can be constructed at the molecular level by monitoring the emission intensity value at 504 nm of the output signal through the input signal (Cu 2+ and EDTA) [ 16 , 74 , 75 , 76 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, when the concentration of absorbed ions is unbalanced, the homeostasis in cells will be affected, leading to a series of diseases [13][14][15]. The multifunctional detection of the same sensor for each detection object is attracting attention due to its high efficiency [16][17][18][19]. As a result, the design and synthesis of new multifunctional fluorescent probes that can simultaneously detect copper and zinc ions are of great significance in biomedical and environmental monitoring applications [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…of the same sensor for each detection object is attracting attention due to its high efficiency [16][17][18][19]. As a result, the design and synthesis of new multifunctional fluorescent probes that can simultaneously detect copper and zinc ions are of great significance in biomedical and environmental monitoring applications [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

et al. 2021

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A new type of conjugated polybenzimidazole (CPBI) was synthesized through a simple polycondensation reaction without metal catalysis, and N-alkylation modification was carried out to solve the problems of solubility and fluorescence properties. A series of nano-microsphere polymers CPBIn with large conjugation, good solubility, and strong fluorescence has been successfully used as “turn-off” fluorescent probes for the first time. The results show that, under suitable N-alkylation conditions, the obtained CPBIn can be used as a highly sensitive and selective fluorescent probe for the detection of Cu2+ and Zn2+ at the same time, and their detection limits are both nM levels. In addition, CPBI2 can be designed as an ultra-sensitive IMPLICATION logic gate at the molecular level, cyclically detecting Cu2+. With the test paper containing CPBI2, easy and quick on-site detection can be achieved. This research provides a new idea for the brief synthesis of multifunctional materials.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

et al. 2021

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“…The BHM was facile synthesized through a Duff reaction using the starting material of 4-(benzo[d]thiazol-2-yl)-2-methoxyphenol (3), which was synthesized via a condensation reaction between 2-aminobenzenethiol and 4-hydroxy-3-methoxybenzaldehyde [36]. The single crystal of BHM was obtained, and its molecular structure is depicted in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

A Benzothiazole-Based Fluorescent Probe for Ratiometric Detection of Al3+ and Its Application in Water Samples and Cell Imaging

Tian

Sun

et al. 2019

IJMS

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An easily prepared benzothiazole-based probe (BHM) was prepared and characterized by general spectra, including 1H NMR, 13C NMR, HRMS, and single-crystal X-ray diffraction. Based on the synergistic mechanism of the inhabitation of intramolecular charge transfer (ICT), the BHM displayed high selectivity and sensitivity for Al3+ in DMF/H2O (v/v, 1/1) through an obvious blue-shift in the fluorescent spectrum and significant color change detected by the naked eye, respectively. The binding ratio of BHM with Al3+ was 1:1, as determined by the Job plot, and the binding details were investigated using FT-IR, 1H NMR titration, and ESI-MS analysis. Furthermore, the BHM was successfully applied in the detection of Al3+ in the Songhua River and on a test stripe. Fluorescence imaging experiments confirmed that the BHM could be used to monitor Al3+ in human stromal cells (HSC).

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Phenoxazine‐based Near‐infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells

Shen

Zheng

Yao

et al. 2020

Chemistry An Asian Journal

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It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are “turn‐off” probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel “turn‐on” near‐infrared (NIR) fluorescent probe PZ‐N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu2+). Upon the addition of Cu2+, the probe could quickly react with Cu2+ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ‐N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ‐N was capable of effectively detecting Cu2+ in living cells.

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A dual-functional chemosensor for fluorescent on-off and ratiometric detection of Cu2+ and Hg2+ and its application in cell imaging

Cited by 40 publications

References 49 publications

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

A Benzothiazole-Based Fluorescent Probe for Ratiometric Detection of Al3+ and Its Application in Water Samples and Cell Imaging

Phenoxazine‐based Near‐infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells

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