A dual-functional implant with an enzyme-responsive effect for bacterial infection therapy and tissue regeneration

Ding, Yao; Hao, Yansha; Yuan, Zhangfu; Tao, Bailong; Chen, Maowen; Lin, Changjian; Liu, Peng; Cai, Kaiyong

doi:10.1039/c9bm01924c

Cited by 79 publications

(61 citation statements)

References 60 publications

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“…165 Recently, ERMs have also been used for the delivery of growth factors to accelerate the healing of bone fractures 159 and scaffold degradation, 166 for enhanced delivery of drugs 153,161 and cells, 167 or for the generation of implants with multifunctional capabilities (i.e., antibacterial and tissue regeneration). 168 For example, degradation of chitosan scaffolds generates inorganic pyrophosphate (PPase),-an inhibitor of physiologic mineralization-. However, with the addition of the enzyme pyrophosphatase (PPase), the scaffold breaks down PP i into two phosphate ions, which are essential for the mineralization of the ECM in a bone healing process 169 (see Fig.…”

Section: Piezoelectric Materialsmentioning

confidence: 99%

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

et al. 2021

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The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as the population ages. Traditionally, smart biomaterials have been thought as those that respond to stimuli. However, the continuous evolution of the field warrants a fresh look at the concept of smartness of biomaterials. This review presents a redefinition of the term “Smart Biomaterial” and discusses recent advances in and applications of smart biomaterials for hard tissue restoration and regeneration. To clarify the use of the term “smart biomaterials”, we propose four degrees of smartness according to the level of interaction of the biomaterials with the bio-environment and the biological/cellular responses they elicit, defining these materials as inert, active, responsive, and autonomous. Then, we present an up-to-date survey of applications of smart biomaterials for hard tissues, based on the materials’ responses (external and internal stimuli) and their use as immune-modulatory biomaterials. Finally, we discuss the limitations and obstacles to the translation from basic research (bench) to clinical utilization that is required for the development of clinically relevant applications of these technologies.

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Section: Piezoelectric Materialsmentioning

confidence: 99%

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

et al. 2021

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“…In nature, bacteria situated in different organs produce certain enzymes such as hydrolytic (e.g., glycosidases) or reductive (e.g., azoreductase) which can degrade different kinds of polysaccharides, for example, cyclodextrin, pectin, dextrin, and chitosan. In the case of enzyme-responsive polymeric nanoplatforms, enzymes are utilized to break up the polymer to obtain desirable properties [110,119].…”

Section: Enzyme-responsive Nanomaterialsmentioning

confidence: 99%

“…Ding et al obtained an enzyme-sensitive nanoplatform (Figure 9) intended to cure infections associated with S. aureus and facilitating the growth of bone tissue in vivo [110]. They reported the fabrication of a titanium-based implant containing mesoporous silica nanoparticles (MSNs) loaded with silver nanoparticles (Ag NPs) coated with multilayer layers of poly(L-glutamic acid) (PG) and polyallylamine hydrochloride (PAH) (LBL@MSN-Ag modified Ti substrates).…”

Section: Enzyme-responsive Nanomaterialsmentioning

confidence: 99%

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Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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“…Very recently, Cai and co-workers reported the fabrication of a glutamyl endonuclease-responsive MSN-based nanoplatform to treat S. aureus -associated osteomyelitis infections, meanwhile, promote bone tissue regeneration [ 79 ]. Glutamyl endonuclease (V8 enzyme) was chosen as antimicrobial release trigger taking the advantage of the overexpression of this enzyme in the microenvironment of S. aureus infection.…”

Section: Stimuli-responsive Antimicrobials Deliverymentioning

confidence: 99%

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Colilla

Vallet‐Regí

2020

IJMS

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The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.

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A dual-functional implant with an enzyme-responsive effect for bacterial infection therapy and tissue regeneration

Abstract: An enzyme-responsive nanoplatform was fabricated on Ti substrates to treat implant-associated bacterial infection and accelerate tissue growth in vivo.

Cited by 79 publications

References 60 publications

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Smart Nanomaterials for Biomedical Applications—A Review

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

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