A Dual-Mode Imaging Catheter for Intravascular Ultrasound Application

Abstract

Both the morphological anatomy and functional parameters such as flow speed of the artery provide valuable information for the evaluation of cardiovascular diseases. Direct measurement of the arterial wall can be achieved by intravascular optical/ultrasound imaging methods, however no functional data are acquired with these methods. Fractional flow reserve (FFR) and Doppler wire have been used to assess the blood flow information, but do not provide cross-sectional images of the artery. This study is the first to design and fabricate a dual mode imaging catheter that contains a forward-looking ultrasonic transducer and a side-looking ultrasonic transducer together in one catheter. This dual-mode catheter not only provides morphological information about the artery, but also a precise measurement of functional flow. The data indicate that the proposed catheter can be used to acquire multiple parameters of the artery with a one-time procedure. This novel one-catheter approach could be used for the functional diagnosis of atherosclerotic arteries.

State-of-the-Art Biosensors in China

“…In addition to Ru(bpy) 3 2+ , quantum dots (QDs) are often used in the field of ECL biosensors as an efficient and stable luminescent [76,77]. In the recent study, Tan et al attached a large number of CdS QDs to chain-like polyethylenimine (PEI) via amide bonding, wrapped the modified PEI on the surface of MIL-53(Al), achieved massive loading of CdS QDs, and finally prepared MOF-based ECL signaling probes [78]. In another study, Deng et al successfully encapsulated ZnSe QDs in Fe (III)-MIL-88B-NH 2 through the in situ growth process.…”

“…The transducers were composed of a piezoelectric layer, a top matching layer, and a backing layer. Tissue phantom experiments indicated that the dual-mode catheter could be possibly used for a one-time acquisition of multiple parameters, such as morphological and functional flow information about the vessel [78]. For calculating fractional flow reserve, a method combining coronary (X-ray) angiography curvature images with intravascular ultrasound cross-section was used to reconstruct the 3D structure.…”

Progress in Probe-Based Sensing Techniques for In Vivo Diagnosis

“…The transducers were composed of a piezoelectric layer, a top matching layer, and a backing layer. Tissue phantom experiments indicated that the dual-mode catheter could be possibly used for a one-time acquisition of multiple parameters, such as morphological and functional flow information about the vessel [ 78 ]. For calculating fractional flow reserve, a method combining coronary (X-ray) angiography curvature images with the intravascular ultrasound cross-section images was used to reconstruct the 3D structure.…”

Advances and trends in ultrasound imaging and therapeutic technology

“…在同一次扫描既 可以获得常规血管内超声图像, 又可以额外获得超高 清的血管内图像, 为血管内斑块诊疗提供了更多有用 的信息. 同时, 最新发展的血管内血流成像技术 [36] 、 高介电换能器技术 [37] 、延迟激励技术 [38] 和编码激励 技术 [39] 都为血管内超声成像技术的实现提供了新的 思路. 另一方面, 在食管和肠道检测技术方面, 最新提 出了胶囊超声成像技术 [40] , 将超声关键部件集成到胶 、减少神经元凋亡 [64] .…”