A dual-responsive fluorescent turn-on sensor for sensitively detecting and bioimaging of hydrazine and hypochlorite in biofluids, live-cells, and plants

Chen, Ruimin; Hu, Tingting; Xing, Shu; Wei, Tao; Chen, Jianbin; Li, Tianduo; Niu, Qingfen; Zhang, Zhengyang; Ren, Huijun; Qin, Xiaoxu

doi:10.1016/j.aca.2022.340735

Cited by 24 publications

(3 citation statements)

References 48 publications

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“…Phenothiazines are important chromophoric and pharmacophoric moieties . With the introduction of a sulfinyl group to them, alternative photoluminescence and pharmaceutical properties , could be furnished. Moreover, asymmetric synthesis of phenothiazine-5-oxides with a sulfur chirality might lead to potential applications in chiral optoelectronic materials , and medicinal chemistry.…”

Section: Resultsmentioning

confidence: 99%

Asymmetric and Sustainable Synthesis of Cyclic Sulfoxides with Low Loading of Bisguanidinium Peroxomolybdate Ion-Pairing Catalyst

Wang,

Zhang,

Zong

2024

ACS Sustainable Chem. Eng.

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Chiral cyclic sulfoxides are valuable heterocyclic building blocks in natural products and pharmaceutically active molecules as well as optoelectronics materials. In view of their manifold applications but limited number of available synthetic methodologies to obtain them, highly enantioselective catalytic approaches to access chiral cyclic sulfoxides are therefore desired. Here, a sustainable and enantioselective oxidation of cyclic sulfides has been developed by employing in situ-generated bisguanidinium peroxomolybdate ion-pairing catalysis. Chiral cyclic sulfoxides bearing different ring sizes and functional groups have been achieved under mild and green conditions with low catalyst loading (0.05–0.5 mol %). The synthetic potentials based on chiral cyclic sulfoxide products have also been demonstrated in preparation of medicinally relevant molecules such as BI 1015550, a candidate drug for the treatment of idiopathic pulmonary fibrosis.

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Section: Resultsmentioning

confidence: 99%

Asymmetric and Sustainable Synthesis of Cyclic Sulfoxides with Low Loading of Bisguanidinium Peroxomolybdate Ion-Pairing Catalyst

Wang,

Zhang,

Zong

2024

ACS Sustainable Chem. Eng.

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“…There have been multiple detection methods reported for hydrazine determination, such as fluorimetry, spectrophotometry, chromatography techniques, , chemiluminescence, surface-enhanced Raman spectroscopy, and electrochemical sensors. , Although the electrochemical sensor method offers one of the simplest and cost-effective approaches with on-field sensing capability, hydrazine oxidation at the bare electrode is poorly catalyzed and requires a high overpotential . Thus, several metal/metal oxide, − metal complex, and organic mediator ,, -modified electrodes were developed.…”

Section: Introductionmentioning

confidence: 99%

Electrochemically Modified Poly(dicyandiamide) Electrodes for Detecting Hydrazine in Neutral pH

Manavalan,

Natarajan,

Adeniyi

et al. 2023

Ind. Eng. Chem. Res.

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A new technique for sensing nanomolar concentrations of hydrazine in water samples is reported. A screen-printed carbon electrode (SPCE) altered using an amine-azo functional group encompassing poly(dicyandiamide) is used in this study. The modified electrode exhibits an enhanced activity toward hydrazine detection at a lower overpotential and broad linear scale between 20 nM and 1 mM, with an accurate sensitivity value of 0.1 nA μm–1 cm–2. To the best of our knowledge, poly(dicyandiamide)-modified electrodes exhibit one of the lowest limits of detection for any metal-free electrode that detects 6.7 nM (S/N = 3) of hydrazine. The method established sufficient selectivity and better recoveries. Finally, the poly(dicyandiamide)-modified SPCE* is highly suitable for electrochemical determination of hydrazine in water samples from tap and lake.

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“…In 2021, Wang [38] and others synthesized a fluorescent probe with double response emission, which was used to detect Fe 3+ and ClO − , and was successfully applied to the intracellular ion tracing of cervical cancer. In 2022, Chen [39] and others developed a new dual-analyte-responsive fluorescent probe based on phenothiazine thiobarbituric acid, which was used for visual recognition and detection of N2H4 and ClO − , with specificity and rapid response.…”

Section: Introductionmentioning

confidence: 99%

A Dual Functional Fluorescent Probe Based on Phenothiazine for Detecting Hg2+ and ClO− and its Applications

Zhang,

Liu,

Nie

et al. 2023

J Fluoresc

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For the efficient detection of Hg 2+ and ClO − , a double-analyte-responsive fluorescent probe PTB was successfully synthesized by combining N-butyl-3-formyl phenothiazine with hydrazine benzothiazole, and designing a specific reaction site for recognizing two analytes (Hg 2+ and ClO − ) in a compound. It was shown that probe PTB successfully formed a stable complex with Hg 2+ in the coordination ratio of 2 : 1 by using the strong sulfur affinity of Hg 2+ , which resulted in a remarkable "turn-off" effect, with a quenching efficiency of 92.5 % and four reversible cycles of Hg 2+ fluorescence detection. For the fluorescence detection of Hg 2+ , the response time is fast (≤ 2 min) and the detection limit is low (7.8 nM), showing extremely high sensitivity, and the performance is obviously better than that of the reported fluorescent probes for detecting Hg 2+ . In particular, probe PTB has low toxicity and good biocompatibility, and has been successfully used for imaging of Hg 2+ in living cells. Moreover, probe PTB uses thioether bond and carbon-nitrogen double bond as reaction sites to detect ClO − , which has large Stokes Shift (149 nm), good selectivity, high quenching efficiency (96.5 %) and fast time response (about 10 s), and successfully detects ClO − in actual water samples.

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A dual-responsive fluorescent turn-on sensor for sensitively detecting and bioimaging of hydrazine and hypochlorite in biofluids, live-cells, and plants

Cited by 24 publications

References 48 publications

Asymmetric and Sustainable Synthesis of Cyclic Sulfoxides with Low Loading of Bisguanidinium Peroxomolybdate Ion-Pairing Catalyst

Asymmetric and Sustainable Synthesis of Cyclic Sulfoxides with Low Loading of Bisguanidinium Peroxomolybdate Ion-Pairing Catalyst

Electrochemically Modified Poly(dicyandiamide) Electrodes for Detecting Hydrazine in Neutral pH

A Dual Functional Fluorescent Probe Based on Phenothiazine for Detecting Hg2+ and ClO− and its Applications

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