A dual‐responsive luminescent sensor for efficient detection of 3‐nitrotyrosine and dipicolinic acid biomarkers based on copper(II) organic framework

Abstract

The trace detection of biomarkers in real samples has profound a most important significance in the early diagnosis and daily monitoring of diseases. Based on the ligand pre‐design strategy, a novel 3D CuMOF, with the formula of {[Cu4(BTPB)(μ2‐OH)2(H2O)5]·3H2O}n, was fabricated by using the hexacarboxyl ligand of 1,4‐bis(2,4,6‐tricarboxylpyrid‐5‐yl)benzene (H6BTPB) and tetranuclear {Cu4(COO)4(μ2‐OH)2} SBUs. Benefiting from the robust framework and unique luminescence performance, the prepared CuMOF displays great potential as a dual‐responsive efficient luminescent sensor in “turn‐off” detection of 3‐nitrotyrosine (3‐NT) biomarker and “turn‐on” detecting the anthrax biomarker of dipicolinic acid (DPA), with detection limits (LOD) for 3‐NT and DPA being 110.8 ng/ml and 85.2 ng/ml, respectively. Additionally, the practicality and compatibility of such developed sensors were verified by quantifying 3‐NT and DPA biomarkers in diluted serum and urine samples with satisfactory recoveries. Further, the theoretical calculations of energy levels as well as the spectral overlap between the analytes and CuMOF were conducted to elucidate the possible sensing mechanisms. This work demonstrated that MOFs‐based luminescent sensors are evolving as an efficacious and equable approach for the detection of biomarkers in real samples.

A Benzothiadiazole-Based Zn(II) Metal–Organic Framework with Visual Turn-On Sensing for Anthrax Biomarker and Theoretical Calculation

“…The Zn-MOF can be used as an effective fluorescence sensor for sensing the biomarker 3-nitrotyrosinea (3-NT) with a K SV value of 6.596 × 10 4 M −1 [ 25 ]. Recently, Fan’s group proposed a Ni(II) metal–organic framework under a mixed-ligand method, and subsequently proved its excellent sensing properties in detecting 3-NT biomarker and HA biomarker in real samples [ 26 ]. As of now, “turn-off” responses (where fluorescence intensity decreases) are frequently used in documented examples to detect any analytes; on the contrary, “turn-on” responses (where fluorescence intensity increases) are uncommon [ 27 ].…”

A luminescent Zn(ii) coordination polymer based on a new tetrazolyl–benzimidazolyl tripodal heterotopic ligand for detecting acetone and triethylamine in water

“…27,28 MOFs have been considered good platforms for constructing luminescent sensors for detecting various pollutants over the past few decades. 29–34 However, the detection of acetone and TEA in water by luminescent MOF sensors is still relatively limited, 22,35 to the best of our knowledge.…”