A dual responsive targeted drug delivery system based on smart polymer coated mesoporous silica for laryngeal carcinoma treatment

Liu, Xueshibojie; Yu, Dan; Jin, Can; Song, Xiaowei; Cheng, Jinzhang; Zhao, Xue; Qi, Xinmeng; Zhang, Guangxin

doi:10.1039/c4nj00579a

Cited by 60 publications

(39 citation statements)

References 30 publications

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“…For example, Zhang et al 35 reported functional MSNs coated with pH and redox dual-responsive polymer consisting of acid-hydrolyzable benzoic-imine bond and reduction-cleavable disulfide linkage. Another example with similar stimuli-responsive property was developed by Wang et al 36 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 5 inside. In neutral or alkaline (e.g.…”

Section: Introductionmentioning

confidence: 96%

Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery

Zhang

Ang

et al. 2015

ACS Appl. Mater. Interfaces

210

107

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In this study, pH, reduction and light triple-responsive nanocarriers based on hollow mesoporous silica nanoparticles (HMSNs) modified with poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) were developed via surface-initiated atom transfer radical polymerization. Both reduction-cleavable disulfide bond and light-cleavable o-nitrobenzyl ester were used as the linkages between HMSNs and pH-sensitive PDEAEMA polymer caps. A series of characterization techniques were applied to characterize and confirm the structures of the intermediates and final nanocarriers. Doxorubicin (DOX) was easily encapsulated into the nanocarriers with a high loading capacity, and quickly released in response to the stimuli of reducing agent, acid environment or UV light irradiation. In addition, flow cytometry analysis, confocal laser scanning microscopy observations and cytotoxicity studies indicated that the nanocarriers were efficiently internalized by HeLa cancer cells, exhibiting (i) enhanced release of DOX into the cytoplasm under external UV light irradiation, (ii) better cytotoxicity against HeLa cells, and (iii) superior control over drug delivery and release. Thus, the triple-responsive nanocarriers present highly promising potentials as a drug delivery platform for cancer therapy.

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Section: Introductionmentioning

confidence: 96%

Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery

Zhang

Ang

et al. 2015

ACS Appl. Mater. Interfaces

210

107

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“…A greater variation can be found in the particle diameter which is also dependent on surface modifications. While some silica nanoparticles are 100–120 nm in diameter others are larger than 200 nm, yet pore sizes are similar (2.5 nm or 3.0 nm, respectively) [ 18 , 19 , 20 ]. However, the denoted particle diameter is also dependent on surface modifications such as coatings and the suspension medium.…”

Section: Msn Synthesis and Characteristicsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

2017

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Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One promising approach is the use of drug delivery vehicles. Here, mesoporous silica nanoparticles (MSN) are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects. MSN excellently fulfill the criteria for nanoparticulate carriers: their distinct structure allows high loading capacity and a plethora of surface modifications. MSN synthesis permits fine-tuning of particle and pore sizes. Moreover, drug release can be tailored through various gatekeeper systems which are for example pH-sensitive or redox-sensitive. Furthermore, MSN can either enter tumors passively by the enhanced permeability and retention effect or can be actively targeted by various ligands. PEGylation prolongs circulation time and availability. A huge advantage of MSN is their explicitly low toxic profile in vivo. Yet, clinical translation remains challenging. Overall, mesoporous silica nanoparticles are a promising tool for innovative, more efficient and safer cancer therapies.

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“…After discussing the controlled drug release in response to the single stimuli, the following section describes the blends of stimuli–responsive materials for more effective response to the cancer microenvironment (Baeza, Guisasola, Ruiz‐Hernández, & Vallet‐Regí, ; Chen et al, ; Chen, Soeriyadi, Lu & Sagnella, ; Fu et al, ; Gui, Wang, & Sun, ; Jiao, Sun, Chang, Lu, & Yang, ; Liu et al, ; Paris, Cabañas, Manzano, & Vallet‐Regí, ; Qian et al, ; Yang et al, ). The multiple stimuli such as pH–temperature, pH–enzyme, light–enzyme, temperature–magnetic field, temperature–ultrasound, temperature–redox potential, and pH–temperature–light have been already tested to trigger drug release for the optimization of chemotherapeutic effect (Table ).…”

Section: Functionalized Mpsnps For Stimuli‐sensitive Drug Deliverymentioning

confidence: 99%

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

Aquib

Farooq

Banerjee

et al. 2019

J Biomedical Materials Res

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For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs‐based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide array of studies have been conducted to functionalize drug‐loaded MPSNPs using targeting ligands and stimuli‐sensitive substances. In addition, anticancer drugs have been precisely delivered to their target sites using MPSNPs, which respond to multi‐stimuli. Furthermore, MPSNPs have been extensively tested for their safety and compatibility. The toxicity level of MPSNPs is substantially lower as compared to that of colloidal silica; however, in oxidative stress, they exhibit cytotoxic features. The biocompatibility of MPSNPs can be improved by modifying their surfaces. This article describes the production procedures, functionalization, and applications of biocompatible MPSNPs in drug delivery.

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A dual responsive targeted drug delivery system based on smart polymer coated mesoporous silica for laryngeal carcinoma treatment

Cited by 60 publications

References 30 publications

Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery

Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

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