A dynamic DNA nanosponge for triggered amplification of gene-photodynamic modulation

Luo, Dan; Lin, Xiangguo; Zhao, Yun; Hu, Jiaying; Mo, Fengye; Song, Gege; Zou, Zhiqiao; Wang, Fuan; Liu, Xiaoqing

doi:10.1039/d2sc00459c

Cited by 18 publications

(13 citation statements)

References 52 publications

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“…Unlike PTT, PDT induces cytotoxic effects by generating reactive oxygen species (ROS), which requires three components: a photosensitizer, molecular oxygen, and light. [45] Several photo sensitizers were integrated with DNA structures such as porphyrin, [46] chlorin e6(Ce6), [47] silicon phthalocyanine dichloride (SiPcCl2), [48] methylene blue [49] and 3,6-bis[2-(1-methylpyridinium) ethynyl]-9-pentylcarbazole diiodide (BMEPC). [50] Recently, Guo et al introduced a nucleic acid nanogel for synergistic cancer photodynamic immunotherapy.…”

Section: Ptt/pdt For Icdmentioning

confidence: 99%

DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy

et al. 2023

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The past few decades have witnessed the evolving paradigm for cancer therapy from nonspecific cytotoxic agents to selective, mechanism‐based therapeutics, especially immunotherapy. In particular, the integration of nanomaterials with immunotherapy is proven to improve the therapeutic outcome and minimize off‐target toxicity in the treatment. As a novel nanomaterial, DNA‐based self‐assemblies featuring uniform geometries, feasible modifications, programmability, surface addressability, versatility, and intrinsic biocompatibility, are extensively exploited for innovative and effective cancer immunotherapy. In this review, the successful employment of DNA nanoplatforms for cancer immunotherapy, including the delivery of immunogenic cell death inducers, adjuvants and vaccines, immune checkpoint blockers as well as the application in immune cell engineering and adoptive cell therapy is summarized. The remaining challenges and future perspectives regarding the pharmacokinetics/pharmacodynamics, in vivo fate and immunogenicity of DNA materials, and the design of intelligent DNA nanomedicine for individualized cancer immunotherapy are also discussed.

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Section: Ptt/pdt For Icdmentioning

confidence: 99%

DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy

et al. 2023

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“…After environmental stimulation, the performance of DNAzyme was increased and the cleavage of RNA was accelerated by a supplementary catalytic co-factor. Notably, the generation of O 2 and 1 O 2 was accelerated as a supplementary treatment, providing concurrently self-enhanced gene-photodynamic cancer therapy [ 73 ]. Future studies ought to focus on the clinical translation of these oligonucleotide-based drugs for cancer therapy.…”

Section: Drug Delivery and Cancer Therapymentioning

confidence: 99%

“…The improvement of antitumor chemotherapy by DNA nanosponges could be attained via the modification of the cell apoptosisassociated gene expression triggered by them [72]. Dynamic DNA nanosponges with appropriate stability and biocompatibility were designed for DNAzyme-mediated gene regulation and programmable tumor-targeted delivery with high efficiency [73]. After environmental stimulation, the performance of DNAzyme was increased and the cleavage of RNA was accelerated by a supplementary catalytic co-factor.…”

Section: Dnazyme Nanospongesmentioning

confidence: 99%

“…These nanosponges were employed for the photothermal therapy of cancers to overcome thermal resistance. Dynamic DNA nanosponges with appropriate stability and biocompatibility were designed for DNAzyme-mediated gene regulation and programmable tumor-targeted delivery with high efficiency [73]. After environmental stimulation, the performance of DNAzyme was increased and the cleavage of RNA was accelerated by a supplementary catalytic co-factor.…”

Section: Dnazyme Nanospongesmentioning

confidence: 99%

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Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances

Iravani

Varma

2022

Nanomaterials

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Nanosponges with three-dimensional (3D) porous structures, narrow size distribution, and high entrapment efficiency are widely engineered for cancer therapy and drug delivery purposes. They protect the molecular agents from degradation and help to improve the solubility of lipophilic therapeutic agents/drugs with targeted delivery options in addition to being magnetized to attain suitable magnetic features. Nanosponge-based delivery systems have been applied for cancer therapy with high specificity, biocompatibility, degradability, and prolonged release behavior. In this context, the drug loading within nanosponges is influenced by the crystallization degree. Notably, 3D printing technologies can be applied for the development of novel nanosponge-based systems for biomedical applications. The impacts of polymers, cross-linkers, type of drugs, temperature, loading and mechanism of drug release, fabrication methods, and substitution degree ought to be analytically evaluated. Eco-friendly techniques for the manufacturing of nanosponges still need to be uncovered in addition to the existing methods, such as solvent techniques, ultrasound-assisted preparation, melting strategies, and emulsion solvent diffusion methods. Herein, the recent advancements associated with the drug delivery and cancer therapy potential of nanosponges (chiefly, cyclodextrin-based, DNAzyme, and ethylcellulose nanosponges) are deliberated, focusing on the important challenges and future perspectives.

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“…Except for detection application, DNAzymes display great potential in gene silencing therapy due to their specific cleavage capability, flexible programmability, and relative stability in physiological environment [85–88] . Wang et al.…”

Section: Therapeutic Applications Of Dnazymesmentioning

confidence: 99%

Stimuli‐Responsive RNA‐Cleaving DNAzyme for Biomedical Application

et al. 2022

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Analysis & Sensing www.analysis-sensing.org Review doi.org/10.1002/anse.202200065DNAzymes are synthetic deoxynucleotide oligomers with catalytic properties selected through in vitro systematic evolution of ligands by exponential enrichment (SELEX) technique. RNAcleaving DNAzymes have attracted increasing attentions in bioanalysis and biomedical applications due to their simple synthesis and modification, stable structure, and high catalytic activity. Especially, their different modes of activity regulation enable their extensive theranostic development. This review introduces the in vitro selection of DNAzymes and some typical ones, followed by the description of various stimuli-responsive regulation strategies on DNAzyme activity, including metal ion cofactors, small molecules, protease, light, and heat. Then the recent advances of DNAzyme-based biosensors, therapeutic applications, cell-cell interaction regulation, and logic operation are summarized. At last, the current challenges and possible development of DNAzyme-based biosensors are discussed.

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A dynamic DNA nanosponge for triggered amplification of gene-photodynamic modulation

Abstract: Oligonucleotide drug delivery approach is provided with a biomimetic, dynamic DNA nanomaterial, which enables disease gene regulation and auxiliary therapy in a controllable and self-boosting manner.

Cited by 18 publications

References 52 publications

DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy

DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy

Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances

Stimuli‐Responsive RNA‐Cleaving DNAzyme for Biomedical Application

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