A environmentally friendly reversed-phase liquid chromatography method for phthalates determination in nail cosmetics

Orsi, Daniela; Gagliardi, Luigi; Porrà, R; Berri, Simona; Chimenti, Paola; Granese, Arianna; Carpani, Irene; Tonelli, Domenica

doi:10.1016/j.aca.2005.09.029

Cited by 72 publications

(27 citation statements)

References 10 publications

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“…Several analytical methods have been developed for determining PAEs by gas chromatography (GC) [7,8], high performance liquid chromatography (HPLC) [9,10] using different preconcentration techniques such as liquid-liquid extraction (LLE) [11], solid-phase microextraction (SPME) [12,13] and solid-phase extraction (SPE) [14][15][16][17] in several types of matrices. Among above-mentioned sample pretreatment procedures, solid-phase extraction based on different types of sorbents such as C 8 [15], organic polymers [16] was widely used.…”

Section: Introductionmentioning

confidence: 99%

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Cai

Shi

et al. 2008

Talanta

157

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Ionic liquid mixed hemimicelles-based solid-phase extraction for the preconcentration of five phthalates in environmental water sample was investigated in this paper. A comparative study on the use of room temperature ionic liquids (RTILs) 1-hexyl-3-methylimidazolium bromide ([C 6 mim]Br) and 1-dodecyl-3-methylimidazolium bromide ([C 12 mim]Br)-coated silica as sorbents was presented. Owing to having bigger adsorption amounts for analytes [C 12 mim], Br-coated silica was selected as SPE material and the five analytes di-ethyl-phthalate (DEP), di-n-propyl-phthalate (DnPP), di-n-butyl-phthalate (DnBP), di-cyclohexyl-phthalate (DcHP) and di-(2-ethylhexyl)-phthalate (DEHP) can be quantitatively extracted under optimal conditions. The analytes retained on the cartridge were desorbed completely with 3 mL methanol (pH 2). Predominant factors influencing the extraction efficiency, such as RTILs concentration, pH value, ionic strength and breakthrough volume were discussed. The proposed method had been applied to determining the five phthalates in four environmental water samples and concentration factor of 600 was achieved easily. Detection limits obtained ranged between 0.12 and 0.17 g/L. The accuracy of this method was evaluated by recovery measurement on spiked samples, and good recovery results (85-107%) with relative standard deviation (R.S.D.) of below 6% were achieved.

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Section: Introductionmentioning

confidence: 99%

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Cai

Shi

et al. 2008

Talanta

157

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“…So far, studies on the detec-tion of phthalates in cosmetics have been somewhat limited [20,21]. EU Commission Cosmetics Directive 96/45/ EC of July 2, 1996, regulates the European Standard Method for the determination of parabens [22].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC‐DAD and GC‐MS methods

Shen¹,

Jiang

Mao

et al. 2007

J of Separation Science

161

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Original PaperSimultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC-DAD and GC-MS methods Studies on the determination of seven kinds of phthalates, i. e. diethyl phthalate, dipropyl phthalate, dibutyl phthalate, benzyl butyl phthalate, dicyclohexyl phthalate, di-(2-ethylhexyl) phthalate, and dioctyl phthalate, and four parabens, i. e. methylparaben, ethylparaben, propylparaben, and butylparaben, in 15 kinds of cosmetic products, including hair sprays, perfumes, deodorants, cream, lotion, etc., by HPLC with diode array detection and GC-MS in electron impact ionization mode with selected-ion monitoring have been carried out. Methods have been developed for both qualitative and quantitative detection of phthalates and parabens. Extraction, clean-up, and analysis procedures have been optimized. HPLC and GC-MS determinations were performed after sonication-assisted extraction with methanol and clean-up with C18 SPE. These techniques permit detection of phthalates at a level of 10.0 -100.0 lg/kg and of parabens at a level of 20.0 -200.0 lg/kg. Overall recoveries were 85 -108% with RSD values of 4.2 -8.8%. Only one of the 15 examined samples was free from phthalates and parabens. The remaining 14 samples were found to contain at least three or more of these phthalates and/or parabens. The predominant phthalates and parabens detected in the studied samples were methylparaben, propylparaben, diethyl phthalate, dibutyl phthalate, dicyclohexyl phthalate, and di-(2-ethylhexyl) phthalate. The residue level is at 1.22 -5289 mg/kg.

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“…There are literature accounts of determination of few substances from cosmetic nail lacquers, such as organic paints [7,8], formaldehyde [9], phthalate esters [10,11]. However, methods of assaying of active substances from this type of formulations are not available in scientific literature.…”

Section: Introductionmentioning

confidence: 99%

Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

Elezović¹,

Elezovic²,

Hadzović³

2011

AJAC

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Nail lacquers represent new drug form specifically designed to treat infected nail plate. They are complex organic solutions with specific assaying problems due to the high content of the polymer and plasticizer. Furthermore, there is a lack of assaying methods of active substances from this type of formulations in scientific literature. We developed derivative UV-spectrophotometric method for determination of fluconazole content in antifungal nail lacquer formulations. The method was validated for specificity, linearity, precision (repeatability), intermediate precision and accuracy (recovery). The method is specific, linear in the range of 99.53 -497.65 μg/ml, precise and showed good recovery (98.79% -101.77% from all six developed formulations). Besides, it is inexpensive, simple and nontoxic, i.e. ecologically acceptable. This method can be used for assaying fluconazole from this type of formulations.

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A environmentally friendly reversed-phase liquid chromatography method for phthalates determination in nail cosmetics

Cited by 72 publications

References 10 publications

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Simultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC‐DAD and GC‐MS methods

Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

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