A facile gold nanoparticle–based ELISA system for detection of osteopontin in saliva: Towards oral cancer diagnostics

Chakraborty, Debolina; Thangaraj, Soundara Viveka; Shyamsundar, Vidyarani; Murhekar, Kanchan; Alex, Sruthi Ann; Chandrasekaran, N.; Ramshankar, Vijayalakshmi; Mukherjee, Amitava

doi:10.1016/j.cca.2017.09.009

Cited by 41 publications

(33 citation statements)

References 33 publications

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“…Besides, gold NPs have contributed remarkably in improving the limit of detection (LOD) in conventional enzyme-linked immunosorbent assay (ELISA) protocol. For example, Chakraborty et al have developed a gold-particle-based ELISA system for osteopontin (overexpressed in tongue tumors) detection, which exhibited high sensitivity [ 75 ].…”

Section: Gold Nanoparticles For Oral Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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Oral cancer is the sixth most common malignant cancer, affecting the health of people with an unacceptably high mortality rate. Despite numerous clinical methods in the diagnosis and therapy of oral cancer (e.g., magnetic resonance imaging, computed tomography, surgery, and chemoradiotherapy), they still remain far from optimal. Therefore, an urgent need exists for effective and practical techniques of early diagnosis and effective therapy of oral cancer. Currently, various types of nanoparticles have aroused wide public concern, representing a promising tool for diagnostic probes and therapeutic devices. Their inherent physicochemical features, including ultrasmall size, high reactivity, and tunable surface modification, enable them to overcome some of the limitations and achieve the expected diagnostic and therapeutic effect. In this review, we introduce different types of nanoparticles that emerged for the diagnosis and therapy of oral cancers. Then, the challenges and future perspectives for nanoparticles applied in oral cancer diagnosis and therapy are presented. The objective of this review is to help researchers better understand the effect of nanoparticles on oral cancer diagnosis and therapy and may accelerate breakthroughs in this field.

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Section: Gold Nanoparticles For Oral Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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“…AuNPs and nanorods have many applications in diagnosis and tumor margin determination. These nanomaterials have been associated with different diagnostic tools and systems, including air scanning electron microscopy [ 249 ], enzyme-linked immunosorbent assay (ELISA) [ 250 ], optical coherence tomography [ 251 ], surface enhanced Raman spectroscopy (SERS) [ 252 , 253 , 254 ], an electrochemical immunosensor [ 255 ], indirect computed tomography and magnetic resonance lymphography [ 256 ], and a biosensor consisting of an upconversion nanoparticle, MMP2-recognized polypeptides, and quenchers [ 257 ]. Such methods were proven to be reproducible [ 250 ], sensitive [ 250 , 257 ], specific [ 250 , 255 , 257 ], stable [ 255 ], accurate [ 253 ], reliable [ 252 ], and/or capable of detecting early-stage cancer [ 251 ].…”

Section: Head Neck and Oral Cancermentioning

confidence: 99%

“…The incorporation of AuNPs have improved the sensitivity of different analyses, such as ELISA [250], optical coherence tomography [251], and surface enhanced Raman spectroscopy [252].…”

Section: Diagnosismentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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“…OPN is a major mediator of inflammation-a key factor in carcinogenesis with multi-functional activities [117,118]. The up-regulation of OPN expression has been identified in a variety of human cancers, including but not limited to breast [119], ovarian [120], prostate [121], and oral cavity cancers [122], lung [123], liver [124], gastric [125], pancreatic [126], and colorectal cancers [127], glioma [128], thyroid carcinoma [129], and melanoma cancer [130]. The WHO technical report identifies breast cancer as the most common cancer among women, with the highest incidence in 2018 (11.6% of all cancers) [1].…”

Section: Osteopontinmentioning

confidence: 99%

Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices

Malecka

Mikuła

Ferapontova

2021

Sensors

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Improved outcomes for many types of cancer achieved during recent years is due, among other factors, to the earlier detection of tumours and the greater availability of screening tests. With this, non-invasive, fast and accurate diagnostic devices for cancer diagnosis strongly improve the quality of healthcare by delivering screening results in the most cost-effective and safe way. Biosensors for cancer diagnostics exploiting aptamers offer several important advantages over traditional antibodies-based assays, such as the in-vitro aptamer production, their inexpensive and easy chemical synthesis and modification, and excellent thermal stability. On the other hand, electrochemical biosensing approaches allow sensitive, accurate and inexpensive way of sensing, due to the rapid detection with lower costs, smaller equipment size and lower power requirements. This review presents an up-to-date assessment of the recent design strategies and analytical performance of the electrochemical aptamer-based biosensors for cancer diagnosis and their future perspectives in cancer diagnostics.

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A facile gold nanoparticle–based ELISA system for detection of osteopontin in saliva: Towards oral cancer diagnostics

Cited by 41 publications

References 33 publications

Nanoparticles for Oral Cancer Diagnosis and Therapy

Nanoparticles for Oral Cancer Diagnosis and Therapy

Nanoparticles in Dentistry: A Comprehensive Review

Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices

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