2020
DOI: 10.1101/2020.04.15.041996
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A facile method of mapping HIV-1 neutralizing epitopes using chemically masked cysteines and deep sequencing

Abstract: 13Identification of specific epitopes targeted by neutralizing antibodies is essential to advance 14 epitope-based vaccine design strategies. We report a methodology for rapid epitope mapping 15 of neutralizing antibodies against HIV-1 Env at single residue resolution, using viral 16 neutralization assays and deep sequencing. We extended our methodology to map multiple 17 specificities of epitopes targeted in polyclonal sera, elicited in immunized animals as well as 18 in HIV-We recently described a methodolog… Show more

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