A facile preparation of dehydro-L-ascorbic acid-methanol solution and its stability.

Ohmori, Mitsuaki; Takagi, Masanosuke

doi:10.1271/bbb1961.42.173

“…[8b, c, d, f] Unfortunately, however, the desired product 7 could not be obtained, in spite of several different reaction conditions being investigated, and only decomposition products were observed. Further oxidation of ascorbic acid with CuO, Ag 2 O, and activated charcoal/O 2 , [30] respectively, also provided the same results. In our final attempt, K 2 Fe(CN) 6 was employed as the oxidant, but unfortunately yielded none of the desired product.…”

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confidence: 56%

Enantioselective Total Syntheses of (+)‐Gallocatechin, (−)‐Epigallocatechin, and 8‐C‐Ascorbyl‐(−)‐epigallocatechin

Lin

¹

,

Chang

²

,

Liu

³

et al. 2013

Chemistry An Asian Journal

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Reading the tea leaves: The enatioselective total syntheses of 8‐C‐ascorbyl‐(−)‐epigallocatechin was accomplished by CuII‐mediated oxidative coupling of ascorbic acid and (−)‐epigallocatechin as a key step. Also, the asymmetric total syntheses of tea‐leaf extracts (+)‐gallocatechin and (−)‐epigallocatechin were achieved by Au‐catalyzed intramolecular cycliarylation of the precursor epoxide and Sharpless dihydroxylation.

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Ascorbic Acid

Kuellmer

¹

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Vitamin C was the first vitamin to be manufactured by chemical synthesis on an industrial scale, and today more vitamin C is produced than any other vitamin. Major suppliers of vitamin C are Hoffmann‐La Roche, BASF, Takeda, and Merck‐Darmstadt. Additional production occurs in Eastern Europe, India, and China. Most of the current industrial production is based on the efficient second synthesis developed by Reichstein and Grüssner in 1934. Various attempts to develop a superior, more economical L ‐ascorbic acid process have been reported since 1934. Much time and effort has been developed to find other methods of vitamin C synthesis by fermentation. The use of the fermentation process for the cost‐effective production of L ‐ascorbic acid, however, requires further improvement. Both epidemiological and biochemical studies indicate that vitamin C may play an important role in the prevention of cancer, cataracts, and other disorders. However, there are many gaps in the knowledge of vitamin C, eg, in its role in nutritional interrelationships and in metabolic interactions, as well as its role in prevention of various diseases in humans. Although much additional knowledge concerning the various factors affecting the ascorbic acid status of humans has been acquired in the past decade, the optimum ascorbic acid intake necessary to maintain peak physical and mental health still needs to be established.

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Ascorbic Acid

Kuellmer¹

2001

Kirk-Othmer Encyclopedia of Chemical Technology

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Vitamin C was the first vitamin to be manufactured by chemical synthesis on an industrial scale, and today more vitamin C is produced than any other vitamin. Major suppliers of vitamin C are Hoffmann‐La Roche, BASF, Takeda, and Merck‐Darmstadt. Additional production occurs in Eastern Europe, India, and China. Most of the current industrial production is based on the efficient second synthesis developed by Reichstein and Grüssner in 1934. Various attempts to develop a superior, more economical L ‐ascorbic acid process have been reported since 1934. Much time and effort has been developed to find other methods of vitamin C synthesis by fermentation. The use of the fermentation process for the cost‐effective production of L ‐ascorbic acid, however, requires further improvement. Both epidemiological and biochemical studies indicate that vitamin C may play an important role in the prevention of cancer, cataracts, and other disorders. However, there are many gaps in the knowledge of vitamin C, eg, in its role in nutritional interrelationships and in metabolic interactions, as well as its role in prevention of various diseases in humans. Although much additional knowledge concerning the various factors affecting the ascorbic acid status of humans has been acquired in the past decade, the optimum ascorbic acid intake necessary to maintain peak physical and mental health still needs to be established.

show abstract

A facile preparation of dehydro-L-ascorbic acid-methanol solution and its stability.

Cited by 20 publications

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Enantioselective Total Syntheses of (+)‐Gallocatechin, (−)‐Epigallocatechin, and 8‐C‐Ascorbyl‐(−)‐epigallocatechin

Enantioselective Total Syntheses of (+)‐Gallocatechin, (−)‐Epigallocatechin, and 8‐C‐Ascorbyl‐(−)‐epigallocatechin

Ascorbic Acid

Ascorbic Acid

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