A facile process for the preparation of organic gel-assisted silica microsphere material for multi-mode liquid chromatography

Recent forensic applications of enhanced chromatographic separation methods

“…New LC phases such as organic gel-assisted Silica Microsphere [42] could operate in multiple separation modes. These microspheres are used in anion-ion exchange chromatography, RPC, and HILIC modes of operation.…”

Hydrogel Coating with Temperature Response Retention Behavior and Its Application in Selective Separation of Liquid Chromatography

“…16,17 Therefore, we first tried to increase the degree of cross-linking of the gel and mixed it with mesoporous silica to obtain an organogel/silica polydisperse composite for mixed mode liquid chromatography. 18 However, due to the wide particle size distribution and the exposed silicon hydroxyl groups on the silica surface, although the use of organic gels can be used for mixed-mode liquid chromatography separation, the column efficiency is below 5000 plate/m. Therefore, our first new strategy is to prepare hydrogel-covered silanol groups on the surface of silica microspheres, 19 which is expected to prevent tailing peaks of the chromatographic column and improve the efficiency of the column.…”

“…The degree of swelling of the hydrogel depends on the properties of the gel itself (hydrophilicity, cross-linking density) and the external environment (solvent properties, temperature, pH value, ionic strength, etc. ). , Therefore, we first tried to increase the degree of cross-linking of the gel and mixed it with mesoporous silica to obtain an organogel/silica polydisperse composite for mixed mode liquid chromatography . However, due to the wide particle size distribution and the exposed silicon hydroxyl groups on the silica surface, although the use of organic gels can be used for mixed-mode liquid chromatography separation, the column efficiency is below 5000 plate/m.…”