A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F_2α Analogs

Abstract

A general synthetic approach has been developed for heterocyclic prostaglandins (PGF2α type) starting from the key intermediate (6). (±) 6 was obtained from (±) ‐Corey lactone. The key intermediate (±) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω‐side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations.