A factor analysis of signs and symptoms of the manic episode with Bech–Rafaelsen Mania and Melancholia Scales

Rossi, Alessandro; Daneluzzo, E.; Arduini, Luca; Domenico, Monia Di; Pollice, R.; Petruzzi, Concetta

doi:10.1016/s0165-0327(00)00228-7

Cited by 33 publications

(31 citation statements)

References 12 publications

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“…Our sleep disturbance factor has also been seen in three previous reports (Dilsaver et al, 1999;Rossi et al, 2001;Sato et al, 2002). There is therefore an accumulating body of evidence to suggest that sleep disturbance acts as an independently of other aspects of disease, such as manic, depressive, and psychotic symptoms.…”

Section: Discussionsupporting

confidence: 85%

“…It included flight of ideas, distractibility, racing thoughts, and increased activity. This factor resembles several factors from previous research (Cassidy et al, 1998; Dilsaver et al, 1999;Rossi et al, 2001;Sato et al, 2002;Serretti et al, 1999). The variable activity change loaded onto this factor as well as factor1, the depressive factor.…”

Section: Discussionsupporting

confidence: 80%

“…Overall, these findings largely agree with previously published studies. A depression factor had been identified in several studies of individuals with bipolar disorder (Cassidy et al, 1998;Dilsaver et al, 1999;Rossi et al, 2001;Sato et al, 2002). Although one study (Sato et al, 2002) differentiated depressive inhibition from depressed mood, our findings did not.…”

Section: Discussioncontrasting

confidence: 52%

“…Several studies have used factor analysis to derive symptom dimensions for bipolar disorder. Most have used small samples in proportion to the number of variables analyzed Akiskal et al, 2001;Benazzi and Akiskal, 2003;Dilsaver et al, 1999;Rossi et al, 2001;Swann et al, 2001;Ventura et al, 2000). Cassidy et al (1998) studies 237 subjects having DSM III-R bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

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A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands

Faraone

Tsuang

2004

Journal of Affective Disorders

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Although twin and adoption show bipolar disorder (BP) has a strong genetic component, few chromosomal regions have been consistently implicated by molecular genetic studies. To address this issue, we sought to determine if quantitative dimensions of bipolar disorder symptoms would be useful for detecting genes that underlie the susceptibility to bipolar disorder. Subjects were 520 individuals diagnosed with bipolar I, bipolar II or schizoaffective disorder, bipolar type who had participated in the NIMH genetics initiative for bipolar disorder. We constructed symptom scores from 29 psychiatric symptoms recorded in the Diagnostic Interview for Genetic Studies (DIGS). Principal components factor analysis followed by a varimax rotation was used to extract symptom dimensions. Factor scores were calculated for all genotyped individuals in the sample, regardless of affection status. Heritable factors were used in a variance-components linkage analysis, which utilized the exact likelihoods of allele-sharing identical-by-descent for each pair of relatives within each pedigree. The principal components factor analysis resulted in five independent dimensions: depressed state, psychosis, sleep disturbances, psychomotor acceleration, and irritability. Two factors were significantly heritable: depression (h 2 =0.53, pb0.001) and irritable vs. euphoric mania (h 2 =0.35, p=0.03). These were subsequently used in a linkage analysis that resulted in LOD scores of b2.0, which are not statistically significant. The five constructs developed through factor analysis appear to be consistent with previous factor analyses. Notably, only the dimensions associated with the type of mood disturbance showed high heritability, which suggests that careful measurements of depression, euphoria and irritability may be particularly useful in clarifying the genetic etiology of bipolar disorder in future studies. D

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands

Faraone

Tsuang

2004

Journal of Affective Disorders

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“…Este fator explicou 36,3% da variância na avaliação basal e 52,2% no dia 1. Em outro estudo 24 envolvendo 124 pacientes com mania (40 homens e 84 mulheres), a análise dos componentes principais encontrou três fatores que explicavam 40,3%da variância. O primeiro fator e o mais forte pode ser chamado de "fator de ativação-euforia" (29,4%), o segundo refere-se aos itens relacionadas à hostilidade-destrutividade (6%) e o terceiro representa transtorno de sono (4,9%).…”

Section: B2) Validade Concorrenteunclassified

Desenvolvimento da versão em português da Escala de Avaliação de Mania de Bech-Rafaelsen (EAM-BR)

Shansis

Berlim

Mattevi

et al. 2004

Rev. psiquiatr. Rio Gd. Sul

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No presente artigo, é apresentado o desenvolvimento da versão em português da Bech-Rafaelsen Mania Rating Scale (BRMaS) de Bech e colaboradores intitulada: Escala de Avaliação de Mania de Bech-Rafaelsen (EAM-BR). A EAM-BR foi desenvolvida para ser aplicada na forma de uma entrevista semi-estruturada breve conduzida pelo clínico. Ela investiga a presença versus a ausência de sintomas maníacos, sua severidade e sua mudança em resposta ao tratamento. São descritas as qualidades psicométricas da escala original. Com este artigo, a comunidade científica passa a dispor em português de mais um importante instrumento para avaliação do estado maníaco.

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Activation in Bipolar Disorders

et al. 2017

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Within the limitations of the data, this synthesis of available evidence broadly supports the elevation of activation as a criterion A symptom for bipolar disorder in DSM-5. Although the importance of activation in bipolar disorders has been acknowledged for more than a century, this review suggests that this critical construct is understudied and should be the topic of more systematic high-quality research.

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A factor analysis of signs and symptoms of the manic episode with Bech–Rafaelsen Mania and Melancholia Scales

Cited by 33 publications

References 12 publications

A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands

A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands

Desenvolvimento da versão em português da Escala de Avaliação de Mania de Bech-Rafaelsen (EAM-BR)

Activation in Bipolar Disorders

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