A fast and dual crosslinking hydrogel based on vinyl ether sodium alginate

Xu, Sishi; Liang, Wencheng; Xu, Guanzhe; Huang, Chengjie; Zhang, Junyong; Lang, Meidong

doi:10.1016/j.apsusc.2020.145811

Cited by 35 publications

(16 citation statements)

References 43 publications

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“…UV-directed thiol-ene click reaction, as an effective method, is extensively employed in the preparation of gels and post-modification of polymers, with the purpose of obtaining qualified hydrogel (Yap et al, 2020). Lang et al (Xu et al, 2020) functionalized sodium alginate backbone to synthesis SA derivatives via grafting vinyl ether (VE) side chains to form amido linkages (-CONH-). A dual crosslinking alginate hydrogel SA-VE/DTT was fabricated through hydrogen-bonded along with thiol-ene click chemistry reaction under UV exposure (Xu et al, 2020).…”

Section: Free-radical Thiol-ene Addition Click Reactionsmentioning

confidence: 99%

“…Lang et al (Xu et al, 2020) functionalized sodium alginate backbone to synthesis SA derivatives via grafting vinyl ether (VE) side chains to form amido linkages (-CONH-). A dual crosslinking alginate hydrogel SA-VE/DTT was fabricated through hydrogen-bonded along with thiol-ene click chemistry reaction under UV exposure (Xu et al, 2020). These systems maintained fast gelation, superior storage modulus, and long-term stability.…”

Section: Free-radical Thiol-ene Addition Click Reactionsmentioning

confidence: 99%

“…The function of wound dressing is to protect the damaged area from bacterial infection, and to provide an appropriate environment to encourage the re-establishment of the skin integrity and homeostasis thus accelerating the healing process (Kujath & Michelsen, 2008;Ma et al, 2019 Vinyl ether side chains were grafted into sodium alginate backbone, thus providing new reaction sites for further cross-linking. The functionalized sodium alginate subsequently formed a series of dual crosslinking hydrogel sodium alginate-vinyl ether/dithiothreitol (SA-VE/DTT) with dithiothreitol under UV exposure (Figure 5) (Xu et al, 2020). The hydrogel system displayed superior mechanical strength, long-term stability, as well as a fast hemostasis behavior when applied for s in rat tail wounds.…”

Section: Wound Dressingmentioning

confidence: 99%

“…Figure 5. crosslinking alginate hydrogel with superior gel properties based on viny ether sodium alginate. (A) Synthesis diagram of SA-VE/DTT hydrogel; (B) Hydrogen bonding verification: SA-VE/H2O hydrogel added with (a) DI water; (b) NaSCN aqueous solutions (3 mol/L); (C) Rat tail hemostasis test results: (a) natural hemostasis; (b) Ca-Alg; (c) SA-VE (Xu et al, 2020). …”

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confidence: 99%

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Alginate modification via click chemistry for biomedical applications

Deng

Shavandi

Okoro

et al. 2021

Carbohydrate Polymers

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Section: Free-radical Thiol-ene Addition Click Reactionsmentioning

confidence: 99%

Section: Free-radical Thiol-ene Addition Click Reactionsmentioning

confidence: 99%

Section: Wound Dressingmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Alginate modification via click chemistry for biomedical applications

Deng

Shavandi

Okoro

et al. 2021

Carbohydrate Polymers

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“…This modification was firstly developed for alginates [ 73 , 74 , 75 , 76 ] and further adapted by Sari et al for ulvans to graft octylamine, using the EDC.HCl coupling agent ( Scheme 3 A). Conjugated alginate was also grafted with an aminopropyl vinyl ether (APVE) using EDC.NHS ( N -hydroxysuccinimide) as coupling agent [ 77 ] ( Scheme 3 B). Other aminoalkylchains were used to modify alginate, such as dodecylamine [ 78 ] or methylamine [ 79 ].…”

Section: Amphiphilic Modifications Of Polysaccharidesmentioning

confidence: 99%

Formation of Amphiphilic Molecules from the Most Common Marine Polysaccharides, toward a Sustainable Alternative?

Wong

Brault

Gasparotto³

et al. 2021

Molecules

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Marine polysaccharides are part of the huge seaweeds resources and present many applications for several industries. In order to widen their potential as additives or bioactive compounds, some structural modifications have been studied. Among them, simple hydrophobization reactions have been developed in order to yield to grafted polysaccharides bearing acyl-, aryl-, alkyl-, and alkenyl-groups or fatty acid chains. The resulting polymers are able to present modified physicochemical and/or biological properties of interest in the current pharmaceutical, cosmetics, or food fields. This review covers the chemical structures of the main marine polysaccharides, and then focuses on their structural modifications, and especially on hydrophobization reactions mainly esterification, acylation, alkylation, amidation, or even cross-linking reaction on native hydroxyl-, amine, or carboxylic acid functions. Finally, the question of the necessary requirement for more sustainable processes around these structural modulations of marine polysaccharides is addressed, considering the development of greener technologies applied to traditional polysaccharides.

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Dual Physically Cross‐Linked Hydrogels Incorporating Hydrophobic Interactions with Promising Repairability and Ultrahigh Elongation

Liu

Yang

et al. 2020

Adv Funct Materials

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Novel dual physically cross-linked (DPC) hydrogels with great tensile strength, ultrahigh elongation, and promising repairability are designed by introducing cellulose nanocrystal (CNC) or hydrophobized CNC (CNC-C8) into polymers physically cross-linked by hydrophobic forces. C18 alkyl chain is grafted to N-[3-(dimethylamino)propyl]methacrylamide (DMAPMA) for hydrophobic monomer (DMAPMA-C18), and C8 to CNC surface for hydrophobic CNC (CNC-C8). CNC-C8 (or CNC) DPC hydrogels are synthesized, with monomers N,N-dimethylacrylamide (DMAc) and DMAPMA-C18 polymerized to form the first network physically cross-linked by hydrophobic interactions, on which the secondary cross-linking points are formed by hydrophobic interactions between CNC-C8 and DMAPMA-C18, electrostatic interactions between CNC-C8 (or CNC) and DMAPMA, as well as hydrogen bonding between CNC-C8 (or CNC) and DMAc. Compared with optimum CNC DPC hydrogels of the highest tensile strength (238 ± 8 kPa), the optimum CNC-C8 DPC hydrogel with 0.0675 w/v% DMAPMA-C18 and 0.4 w/v% CNC-C8 possesses stronger tensile strength of 331 ± 32 kPa and excellent elongation of 4268% ± 1446% as well, demonstrating the enhanced mechanical property of the hydrogel by introduced hydrophobic interactions. In addition, such DPC hydrogel can be facilely repaired with tetrahydrofuran (THF) on the cut surfaces while retaining good tensile stress and elongation behaviors.

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A fast and dual crosslinking hydrogel based on vinyl ether sodium alginate

Cited by 35 publications

References 43 publications

Alginate modification via click chemistry for biomedical applications

Alginate modification via click chemistry for biomedical applications

Formation of Amphiphilic Molecules from the Most Common Marine Polysaccharides, toward a Sustainable Alternative?

Dual Physically Cross‐Linked Hydrogels Incorporating Hydrophobic Interactions with Promising Repairability and Ultrahigh Elongation

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