A fast pH-responsive IPN hydrogel: Synthesis and controlled drug delivery

Wu, Wen; Wang, Dongsheng

doi:10.1016/j.reactfunctpolym.2010.06.002

Cited by 51 publications

(26 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, these hydrogels have important applications in the field of medicine, pharmacy, and biotechnology. [31][32][33][34][35][36] Semi-IPN hydrogels of chitosan have been investigated by researchers. For instance, semi-IPN hydrogels of chitosan with polyether, 37 poly(acrylic acid), 38 poly(ethylene glycol), 39 and poly(N-isopropylacrylamide) 40 have been reported.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Swelling Properties of Chitosan/Poly(acrylic acid-co-crotonic acid) Semi-Interpenetrating Polymer Networks

Hosseinzadeh¹,

Alijani²

2014

Polymer Korea

View full text Add to dashboard Cite

A semi-interpenetrating polymer network (semi-IPN) hydrogel composed of crosslinked chitosan and poly (acrylic acid-co-crotonic acid) was prepared in the presence of glutaraldehyde (GA) as a crosslinker. Fourier-transform infrared, thermogravimetric analysis and scanning electron microscopy were employed to confirm the structure of the semi-IPN hydrogel. The swelling capacity of hydrogel was shown to be affected by the monomers weight ratio, chitosan content, initiator and GA concentrations. The results also indicated that the semi-IPN hydrogel had different swelling capacity at various pHs. Additionally, the swelling behavior of the hydrogel was investigated in aqueous solutions of NaCl, CaCl 2 , and AlCl 3 .

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Swelling Properties of Chitosan/Poly(acrylic acid-co-crotonic acid) Semi-Interpenetrating Polymer Networks

Hosseinzadeh¹,

Alijani²

2014

Polymer Korea

View full text Add to dashboard Cite

show abstract

“…Some interesting drug delivery systems based on hydrogels have thus been proposed [5][6][7] . Among hydrogels, however, considerable research attention has been ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org focused on so-called "smart" hydrogels which can transfer their volume in response to environmental stimuli, and these results in environmental stimuli modifying drug release.…”

Section: Introductionmentioning

confidence: 99%

Biosuperabsorbent Hydrogel Based on Alginate-g-poly AA/kaolin Composite for Releasing Cefalexin Drug

Sadeghi¹,

Shafiei²,

Mohammadinasab³

2014

Orient. J. Chem

View full text Add to dashboard Cite

To following synthesis of a novel alginte-based composite superabsorbent hydrogel was through crosslinking graft copolymerization of acrylic acid onto alginate in presence kaolin, we investigated the usefulness of a pH-sensitive protein-based hydrogel for in vitro controlled release of cefalexin. The loading drug yield was found to depend on the incubation time, the amount of encapsulated drug. In addition, the release of cefalexin from this kind of hydrogel was studied. The release rate of cefalexin from hydrogel at pH 7.4 was faster than that at pH 1.6 due to the shrinkage of the hydrogel at pH 1.6.

show abstract

“…Due to unique properties of SAPs, these polymers was synthesized and characterized by the several research groups in the world [2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and swelling properties of a poly(vinyl alcohol)-based superabsorbing hydrogel

Hosseinzadeh

2013

10.5267/j.ccl

View full text Add to dashboard Cite

Superabsorbent hydrogels based on poly(vinyl alcohol) were prepared by a crosslinking technique using glutaraldehyde as a crosslinker. The hydrogel structure was confirmed using scanning electron microscopy (SEM). Results from SEM observation showed a porous structure with smooth surface morphology of the hydrogel. We have systematically optimized the certain variables of hydrogel synthesis (i.e. the crosslinker concentration, poly(vinyl alcohol) content, time and temperature of crosslinking reaction) to achieve a hydrogel with maximum water absorbency. It was concluded that under the optimized conditions, maximum capacity of swelling in distilled water was equal to 231 g/g. The absorbency under load (AUL) of hydrogels was also measured. In addition, swelling ratio in various salt solutions was determined and the hydrogels exhibited salt-sensitivity properties.

show abstract

A fast pH-responsive IPN hydrogel: Synthesis and controlled drug delivery

Cited by 51 publications

References 34 publications

Synthesis, Characterization and Swelling Properties of Chitosan/Poly(acrylic acid-co-crotonic acid) Semi-Interpenetrating Polymer Networks

Synthesis, Characterization and Swelling Properties of Chitosan/Poly(acrylic acid-co-crotonic acid) Semi-Interpenetrating Polymer Networks

Biosuperabsorbent Hydrogel Based on Alginate-g-poly AA/kaolin Composite for Releasing Cefalexin Drug

Synthesis and swelling properties of a poly(vinyl alcohol)-based superabsorbing hydrogel

Contact Info

Product

Resources

About