A Feasibility Study for 3D-printed Poly(methyl methacrylate)-resin Tracheostomy Tube Using a Hamster Cheek Pouch Model

Jung, Harry; Lee, Ji Seung; Lee, Jun Ho; Park, Ki Joon; Lee, Jae Jun; Park, Hae Sang

doi:10.21873/invivo.11968

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…Overall, the filler-loaded PMMA-based resin is considered suitable for use in dental applications, such as temporary crowns, provisional restorations, and denture bases. However, there is scope for further assessment of the cytotoxicity of PMMA-based reins to confirm their biocompatibility using human gingival fibroblasts and gingival keratinocytes [ 47 ] and in vivo allergy tests [ 48 ]. Since TEGDMA has a risk of disruption of vital cell functions, the cytotoxicity due to the unpolymerized monomers will be examined further [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Dental Poly(methyl methacrylate)-Based Resin Containing a Nanoporous Silica Filler

Hata

Ikeda

Nagamatsu

et al. 2022

JFB

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Poly(methyl methacrylate) (PMMA)-based resins have been conventionally used in dental prostheses owing to their good biocompatibility. However, PMMA-based resins have relatively poor mechanical properties. In the present study, a novel nanoporous silica filler was developed and introduced into PMMA-based resins to improve their mechanical properties. The filler was prepared by sintering a green body composed of silica and an organic binder, followed by grinding to a fine powder and subsequent silanization. The filler was added to photocurable PMMA-based resin, which was prepared from MMA, PMMA, ethylene glycol dimethacrylate, and a photo-initiator. The filler was characterized by scanning electron microscopy (SEM), X-ray diffraction analysis, nitrogen sorption porosimetry, and Fourier transform infrared (FT-IR) spectroscopy. The PMMA-based resins were characterized by SEM and FT-IR, and the mechanical properties (Vickers hardness, flexural modulus, and flexural strength) and physicochemical properties (water sorption and solubility) were evaluated. The results suggested that the filler consisted of microparticles with nanopores. The filler at 23 wt % was well dispersed in the PMMA-based resin matrix. The mechanical and physicochemical properties of the PMMA-based resin improved significantly with the addition of the developed filler. Therefore, such filler-loaded PMMA-based resins are potential candidates for improving the strength and durability of polymer-based crown and denture base.

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Section: Discussionmentioning

confidence: 99%

Dental Poly(methyl methacrylate)-Based Resin Containing a Nanoporous Silica Filler

Hata

Ikeda

Nagamatsu

et al. 2022

JFB

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“…The current findings imply that the cytotoxicity of the PMMA-based resin may be acceptable for use in an oral environment. The biocompatibility of the PMMA-based resins will be further clarified using in vitro cytotoxicity using human gingival cells [47] and in vitro allergy tests [48] in future work.…”

Section: Discussionmentioning

confidence: 99%

Development of Dental Poly(methyl methacrylate)-Based Resin for Stereolithography Additive Manufacturing

et al. 2021

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Poly(methyl methacrylate) (PMMA) is widely used in dental applications. However, PMMA specialized for stereolithography (SLA) additive manufacturing (3D-printing) has not been developed yet. This study aims to develop a novel PMMA-based resin for SLA 3D-printing by mixing methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and PMMA powder in various mixing ratios. The printability and the viscosity of the PMMA-based resins were examined to determine their suitability for 3D-printing. The mechanical properties (flexural strength and Vickers hardness), shear bond strength, degree of conversion, physicochemical properties (water sorption and solubility), and cytotoxicity for L929 cells of the resulting resins were compared with those of three commercial resins: one self-cured resin and two 3D-print resins. EGDMA and PMMA were found to be essential components for SLA 3D-printing. The viscosity increased with PMMA content, while the mechanical properties improved as EGDMA content increased. The shear bond strength tended to decrease as EGDMA increased. Based on these characteristics, the optimal composition was determined to be 30% PMMA, 56% EGDMA, 14% MMA with flexural strength (84.6 ± 7.1 MPa), Vickers hardness (21.6 ± 1.9), and shear bond strength (10.5 ± 1.8 MPa) which were comparable to or higher than those of commercial resins. The resin’s degree of conversion (71.5 ± 0.7%), water sorption (19.7 ± 0.6 μg/mm3), solubility (below detection limit), and cell viability (80.7 ± 6.2% at day 10) were all acceptable for use in an oral environment. The printable PMMA-based resin is a potential candidate material for dental applications.

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“…Recent reports indicate that, for the moment, the mixes of PMMA compatible with VPP 3D printing techniques are for dental technologies and implants [135][136][137], although a few studies have reported additional medical uses [138]. The notable characteristics of PMMAbased constructs include their good aesthetics, physicochemical properties, low cost, excellent biocompatibility, low toxicity, reliability, and good mechanical strength [130,132,133].…”

Section: Poly(methyl Methacrylate)mentioning

confidence: 99%

“…An innovative study using DLP-printed PMMA successfully built a tracheostomy tube which was later tested and functioned properly with no infections, allergies, or other reactions in rabbits [138]. It was reported that the PMMA-resin scaffold exhibited no fiber structures, contaminations, or surface cracks and also that cell viability was higher than in the control groups.…”

Section: Poly(methyl Methacrylate)mentioning

confidence: 99%

“…It was reported that the PMMA-resin scaffold exhibited no fiber structures, contaminations, or surface cracks and also that cell viability was higher than in the control groups. The key advantages include the precision and speed of the print, the enhanced mechanical behavior pre-and post-insertion, and the absence of cytotoxic effects and visible chemical changes in vivo [138].…”

Section: Poly(methyl Methacrylate)mentioning

confidence: 99%

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Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications

Timofticiuc,

Călinescu,

Iftime

et al. 2023

JFB

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Along with the rapid and extensive advancements in the 3D printing field, a diverse range of uses for 3D printing have appeared in the spectrum of medical applications. Vat photopolymerization (VPP) stands out as one of the most extensively researched methods of 3D printing, with its main advantages being a high printing speed and the ability to produce high-resolution structures. A major challenge in using VPP 3D-printed materials in medicine is the general incompatibility of standard VPP resin mixtures with the requirements of biocompatibility and biofunctionality. Instead of developing completely new materials, an alternate approach to solving this problem involves adapting existing biomaterials. These materials are incompatible with VPP 3D printing in their pure form but can be adapted to the VPP chemistry and general process through the use of innovative mixtures and the addition of specific pre- and post-printing steps. This review’s primary objective is to highlight biofunctional and biocompatible materials that have been adapted to VPP. We present and compare the suitability of these adapted materials to different medical applications and propose other biomaterials that could be further adapted to the VPP 3D printing process in order to fulfill patient-specific medical requirements.

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A Feasibility Study for 3D-printed Poly(methyl methacrylate)-resin Tracheostomy Tube Using a Hamster Cheek Pouch Model

Cited by 3 publications

References 23 publications

Dental Poly(methyl methacrylate)-Based Resin Containing a Nanoporous Silica Filler

Dental Poly(methyl methacrylate)-Based Resin Containing a Nanoporous Silica Filler

Development of Dental Poly(methyl methacrylate)-Based Resin for Stereolithography Additive Manufacturing

Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications

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