A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the multi electrode current source (MECS) system

Abstract

Despite the spatial steering capabilities of the MECS-IHT system, a large temperature heterogeneity was encountered. The heterogeneity was the reason to limit the catheter spacing to 11-12 mm, thus making only small tumour volumes feasible for interstitial heating.

Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?

“…The HT group showed significantly increased survival (2y-survival 31% vs. 15%, p  = 0.02) and time to progression (TTP) (median TTP 49 vs. 33 months, p  = 0.045); however, this treatment was accompanied by increased grade 3 toxicity rates. In recent years, efforts were made to optimize HT delivery by improving interstitial catheters or applying focused ultrasound (113, 114). No data exist so far validating these new techniques or the combination with temozolomide.…”

Assessment of cytotoxic damage induced by irradiation combined with hyperthermia and Gemcitabine on cultured glioblastoma spheroid cells

“…Heating increases DNA damages induced by irradiation and also protein injuries. Heat has an important role in prevention of DNA repair (Engin, 1994;Hulshof et al, 2004).…”

“…Therefore these cells will be more sensitive to the ionizing radiations and certain anticancer drugs. Hyperthermia has been used for many years and has led promising results in cancer treatment (Engin, 1994;Hulshof et al, 2004).…”

What is on the Horizon for Hyperthermic Cancer Therapy?

“…Hyperthermia inhibits angiogenesis, the contrast of the tumor becomes clearer, and turning previously inoperable cases to successfully operated ones [104,105]. The postoperative application of hyperthermia is also applied [106], and the minimally invasive radiofrequency ablation [107] and local hyperthermia [108] have been used to improve surgical results. Postoperative application to the brain has also been published [10], using an interstitial method (minimally invasive treatment using needles as electrodes in the tumor itself).…”