A feasibility study of temperature rise measurement in a tissue phantom as an alternative way for characterization of the therapeutic high intensity focused ultrasonic field

Chen, Di; Fan, Tingbo; Zhang, Dong; Wu, Junru

doi:10.1016/j.ultras.2009.05.008

Cited by 18 publications

(15 citation statements)

References 19 publications

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“…Their temperature results were compared to an analytical model for tissue heating based on a linear acoustic absorption theory. Chen et al 21 embedded a gelatin-based TMM with a 0.125 mm thermocouple and compared the temperature with predicted values from simple linear and nonlinear Gaussian models. Jensen et al 22 sonicated ex vivo ox liver samples embedded with 200 lm-diameter mini-hypodermic thermocouples.…”

Section: Introductionmentioning

confidence: 99%

Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields

Maruvada

Liu

Soneson

et al. 2015

The Journal of the Acoustical Society of America

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For high intensity therapeutic ultrasound (HITU) devices, pre-clinical testing can include measurement of power, pressure/intensity and temperature distribution, acoustic and thermal simulations, and assessment of targeting accuracy and treatment monitoring. Relevant International Electrotechnical Commission documents recently have been published. However, technical challenges remain because of the often focused, large amplitude pressure fields encountered. Measurement and modeling issues include using hydrophones and radiation force balances at HITU power levels, validation of simulation models, and tissue-mimicking material (TMM) development for temperature measurements. To better understand these issues, a comparison study was undertaken between simulations and measurements of the HITU acoustic field distribution in water and TMM and temperature rise in TMM. For the specific conditions of this study, the following results were obtained. In water, the simulated values for p+ and p- were 3% lower and 10% higher, respectively, than those measured by hydrophone. In TMM, the simulated values for p+ and p- were 2% and 10% higher than those measured by hydrophone, respectively. The simulated spatial-peak temporal-average intensity values in water and TMM were greater than those obtained by hydrophone by 3%. Simulated and measured end-of-sonication temperatures agreed to within their respective uncertainties (coefficients of variation of approximately 20% and 10%, respectively).

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Section: Introductionmentioning

confidence: 99%

Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields

Maruvada

Liu

Soneson

et al. 2015

The Journal of the Acoustical Society of America

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“…12 Another possible mechanism is that ultrasound increases the local temperature around CPC, which results in an increase in gentamicin release. 13 …”

Section: Discussionmentioning

confidence: 99%

Low-intensity pulsed ultrasound enhances antibiotic release of gentamicin-loaded, self-setting calcium phosphate cement

et al. 2018

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ObjectiveThis study aimed to investigate the effect of low-intensity pulsed ultrasound on antibiotic release from gentamicin-loaded, self-setting calcium phosphate cement.MethodsA gentamicin-loaded calcium phosphate cement cylinder was eluted in stimulated body fluid. Low-intensity pulsed ultrasound (46.5 kHz, 200 mW/cm2) was used to produce a sinusoidal wave in the experimental group. Non-gentamicin calcium phosphate cement was used in the control group.ResultsThe transient concentration and cumulatively released percentage of gentamicin in the ultrasound group were higher than those in control group at every time point. The duration of gentamicin concentrations over the level of the minimum inhibitory concentration was significantly prolonged in the ultrasound group compared with the control group. Antibacterial efﬁcacy of gentamicin in the ultrasound group was significantly better than that in the control group with the same concentration of gentamicin.ConclusionLow-intensity pulsed ultrasound enhances antibiotic release, providing sustained antibiotic release at high concentrations. This increases the antibacterial effect of gentamicin.

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“…Soneson and Myers [17,18] and Chen et al [19] expanded the Gaussian model to a focused nonlinear US beam and showed that the accuracy of modeling a HIFU beam using a focused nonlinear Gaussian beam matched well with that of simulations done by using a traditional finite-difference code for the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation [20]. They indicated that the intensity of a HIFU beam I(q, n) can be written as a superposition of infinite numbers of harmonics I n (q, n), where n = 1 corresponding to the intensity of the fundamental frequency f 1 = f 0 and n = 2, 3, .…”

Section: A Nonlinear Gaussian Beam Modelmentioning

confidence: 98%

“…Under the conditions 2pa k ¼ 2pf 0 a c ) 1 (the transducer radius is much larger than the wavelength) and d ) ffiffiffiffiffiffiffiffiffi ðjtÞ p (heat conduction characterization distance is much smaller than the focal length), at the focus Eq. (10) can be integrated and simplified to [18,19] …”

Section: Temperature Elevation Calculationsmentioning

confidence: 99%

Preliminary ex vivo feasibility study on targeted cell surgery by high intensity focused ultrasound (HIFU)

Wang

Fang

et al. 2011

Ultrasonics

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A feasibility study of temperature rise measurement in a tissue phantom as an alternative way for characterization of the therapeutic high intensity focused ultrasonic field

Cited by 18 publications

References 19 publications

Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields

Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields

Low-intensity pulsed ultrasound enhances antibiotic release of gentamicin-loaded, self-setting calcium phosphate cement

Preliminary ex vivo feasibility study on targeted cell surgery by high intensity focused ultrasound (HIFU)

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