A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation

Müller, Lisa; Gutschner, Tony; Hatzfeld, Mechthild

doi:10.1016/j.isci.2024.110762

iScience

2024

DOI: 10.1016/j.isci.2024.110762

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A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation

Lisa Müller,

Tony Gutschner,

Mechthild Hatzfeld

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2024

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YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

Pankratova,

Riabinin,

Butova

et al. 2024

IJMS

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The paralogues Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) control cell proliferation and cell fate determination from embryogenesis to ageing. In the skin epidermis, these proteins are involved in both homeostatic cell renewal and injury-induced regeneration and also drive carcinogenesis and other pathologies. YAP and TAZ are usually considered downstream of the Hippo pathway. However, they are the central integrating link for the signalling microenvironment since they are involved in the interplay with signalling cascades induced by growth factors, cytokines, and physical parameters of the extracellular matrix. In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling molecules at the plasma membrane, cytoplasmic, and nuclear levels; and how YAP/TAZ ultimately controls transcription programmes, defining epidermal cell fate.

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YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

Pankratova,

Riabinin,

Butova

et al. 2024

IJMS

View full text Add to dashboard Cite

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A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation

Cited by 1 publication

References 59 publications

YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

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