A Fermented Ginseng Extract, BST204, Inhibits Proliferation and Motility of Human Colon Cancer Cells

Abstract

a These two authors equally contributed to this work.Received Nov 25, 2010 Revised Jan 13, 2011 (Choi et al., 2009;Kumar et al., 2009;Liu et al., 2009).Among the ginsenosides, Rh2 has attracted considerable attention owing to its potential tumor-inhibitory activity against various cancer cells (Park et al

Ginsenoside Rp1 Inhibits Proliferation and Migration of Human Lung Cancer Cells

“…3), similar to previous reports (Park et al, 2008). These fi ndings are clearly distinct from other ginsenoside derivatives which repress MMP activities (Yue et al, 2006;Park et al, 2011), treated with or without G-Rp1 (10, 20 μM) for 30 min, followed by 10% serum stimulation for 15 min. Cell lysates were Western-blotted with anti-phospho-ERK, anti-ERK, anti-phospho-Akt, anti-Akt, anti-phospho-p70 S6K , or anti-p70 S6K antibodies.…”

Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer's disease experimental models

“…FG contains high levels of Rg3, Rg5, and Rk1 that have been bio-converted from Re, Rg1, and Rb1. Recently, FG was found to have hypolipidemic and hypoglycemic effects [12,13] as well as anti-cancer [14], anti-inflammatory [15,16], and therapeutic effects on allergic rhinitis in clinical patients [17]. However, there are no reports on the effect of FG on cognition impairment or AD.…”

Preventive and Therapeutic Roles of Ginseng - Focus on Colon Cancer

“…Treatment of HT-29 cells with a fermented ginseng extracts using high concentration of effective ginsenosides causing enhanced the antiproliferative and the anti-invasive activity against human colon cancer cells (Park et al, 2011).in other study treatment of HCT116 and SW480 colorectal cancer cells with ginsenoside Rh2 activated the p53 pathway and significantly increased the levels of the pro-apoptotic regulator, Bax and decreased the levels of anti-apoptosis regulator Bcl-2. The anti-cancer effect of Rh2 was enhanced by antioxidants .also treatment of HT-29 colorectal cancer cells with Ginseng polysaccharide fraction shown the increased in antiproliferative effect (Cheng et al, 2011).…”

“…This beneficial effect of ginsenosides might be due to cell cycle arrest in cancer. It seems that the G1 phase and G1/S checkpoint are blocked by different mechanisms of ginsenosides Park et al, 2011) .this cell arrest is involved with tumor suppressor proteins up-regulation of P53 and P21 tumors and down regulation of cyclin and CDK including the CDK 2, cyclin E and D1 in G1 phase and G1/S checkpoint (Park et al, 2011).…”