“…While 3-methoxytyrosine might regulate immune cell responses by modulating enzyme activities, the latter's role remains elusive but could be tied to neurotransmitter pathways and their influence on allergic reactions. 32 , 33 In the realm of cofactors and vitamins, threonate emerged with its association, potentially reflecting its antioxidant capabilities or its integral role in collagen synthesis in ocular tissues, 34 both of which can be pivotal in maintaining ocular health during allergenic assaults. Interestingly, the xenobiotic, metoprolol acid metabolite, underscores the possible interactions between medication metabolites and AC, suggesting that certain drug breakdown products could modulate the allergic response, 35 either by influencing immune responses or by altering ocular tissue's receptivity to allergens.…”