A Filter Supported Surface-Enhanced Raman Scattering “Nose” for Point-of-Care Monitoring of Gaseous Metabolites of Bacteria

Guo, Jiansheng; Liu, Ying; Yu, Y. B.; Li, Yumei; Wang, Ruiyong; Ju, Huangxian

doi:10.1021/acs.analchem.9b05400

Cited by 32 publications

(17 citation statements)

References 48 publications

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“…The SERS spectra acquired after 1 day of exposure proved the detection of gaseous metabolites with a sensitivity of 10 nM, comparable to mass spectrometry and much lower than earlier reports on gas chromatography. 225 Other approaches implemented more sophisticated methods, intended to enhance the adsorption of gas molecules onto solid SERS substrates, e.g., by covering the substrates with polymer layers carrying different functionalities or involving microfluidic devices. 226 , 227 More complex systems comprising metal–organic frameworks (MOFs), such as ZIF-8 to coat gold particles, are of particular interest.…”

Section: Updating Sers Sensors For the Near Futurementioning

confidence: 99%

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

et al. 2022

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Future precision medicine will be undoubtedly sustained by the detection of validated biomarkers that enable a precise classification of patients based on their predicted disease risk, prognosis, and response to a specific treatment. Up to now, genomics, transcriptomics, and immunohistochemistry have been the main clinically amenable tools at hand for identifying key diagnostic, prognostic, and predictive biomarkers. However, other molecular strategies, including metabolomics, are still in their infancy and require the development of new biomarker detection technologies, toward routine implementation into clinical diagnosis. In this context, surface-enhanced Raman scattering (SERS) spectroscopy has been recognized as a promising technology for clinical monitoring thanks to its high sensitivity and label-free operation, which should help accelerate the discovery of biomarkers and their corresponding screening in a simpler, faster, and less-expensive manner. Many studies have demonstrated the excellent performance of SERS in biomedical applications. However, such studies have also revealed several variables that should be considered for accurate SERS monitoring, in particular, when the signal is collected from biological sources (tissues, cells or biofluids). This Perspective is aimed at piecing together the puzzle of SERS in biomarker monitoring, with a view on future challenges and implications. We address the most relevant requirements of plasmonic substrates for biomedical applications, as well as the implementation of tools from artificial intelligence or biotechnology to guide the development of highly versatile sensors.

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Section: Updating Sers Sensors For the Near Futurementioning

confidence: 99%

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

et al. 2022

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“…The SERS signals of gaseous metabolites were easily detected by a portable Raman spectrometer by placing the “nose” above the sample infected by bacteria, including Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa . Adapted with permission from ref . Copyright 2020, American Chemical Society.…”

Section: Recent Engineering Approaches For the Detection Of Pathogeni...mentioning

confidence: 99%

Recent Innovations in Bacterial Infection Detection and Treatment

2021

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Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic resistance. These infections can result in tremendous morbidity and mortality, emphasizing the need to identify and treat pathogenic bacteria quickly and effectively. Recent developments in detection methods have focused on electrochemical, optical, and mass-based biosensors. Advances in these systems include implementing multifunctional materials, microfluidic sampling, and portable data-processing to improve sensitivity, specificity, and ease of operation. Concurrently, advances in antibacterial treatment have largely focused on targeted and responsive delivery for both antibiotics and antibiotic alternatives. Antibiotic alternatives described here include repurposed drugs, antimicrobial peptides and polymers, nucleic acids, small molecules, living systems, and bacteriophages. Finally, closed-loop therapies are combining advances in the fields of both detection and treatment. This review provides a comprehensive summary of the current trends in detection and treatment systems for bacterial infections.

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“…The "nose" had a good reproducibility when it used for the quantitative detection of gas targets by SERS ( Figure 6). [86] 3. Label-Based Bacterial Detection Using SERS…”

Section: Detection Signals Originating From Bacterial Metabolitesmentioning

confidence: 99%

Section: Sers Tags and Raman Reporter Moleculesmentioning

confidence: 99%

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

et al. 2020

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The rapid, highly sensitive, and accurate detection of bacteria is the focus of various fields, especially food safety and public health. Surface-enhanced Raman spectroscopy (SERS), with the advantages of being fast, sensitive, and nondestructive, can be used to directly obtain molecular fingerprint information, as well as for the on-line qualitative analysis of multicomponent samples. It has therefore become an effective technique for bacterial detection. Within this progress report, advances in the detection of bacteria using SERS and other compatible techniques are discussed in order to summarize its development in recent years. First, the enhancement principle and mechanism of SERS technology are briefly overviewed. The second part is devoted to a label-free strategy for the detection of bacterial cells and bacterial metabolites. In this section, important considerations that must be made to improve bacterial SERS signals are discussed. Then, the label-based SERS strategy involves the design strategy of SERS tags, the immunomagnetic separation of SERS tags, and the capture of bacteria from solution and dye-labeled SERS primers. In the third part, several novel SERS compatible technologies and applications in clinical and food safety are introduced. In the final part, the results achieved are summarized and future perspectives are proposed.

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A Filter Supported Surface-Enhanced Raman Scattering “Nose” for Point-of-Care Monitoring of Gaseous Metabolites of Bacteria

Cited by 32 publications

References 48 publications

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

Recent Innovations in Bacterial Infection Detection and Treatment

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

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