A Flow Cytometric, Clinical, and Histological Study of Stromal Neoplasms of the Gastrointestinal Tract

Abdominal gastrointestinal stromal tumours: a study of twelve patients

“…Tumours in the small intestine are known to behave most aggressively than those in the stomach. Metastasis at the time of presentation and primary seedling at the time of primary operation, both have very poor prognosis 12,13 . Lymphadenopathy is characteristically absent and it is difficult to differentiate GISTs from lymphoma, metastasis or an adenocarcinoma.…”

Gastrointestinal stromal tumors: A multicenter study of 1160 Turkish cases

“…Fifty to 70% of lesions arise in the stomach, 20% to 30% in the small bowel, 10% in the large bowel, 5% in the esophagus, and 5% elsewhere in the abdominal cavity (1,7,12,16,17,20,(23)(24)(25) nally, the tumors may be multicentric (1,2,7,21). In our study, the stomach and small intestine were the most common locations, while the frequency of large intestine location (10.0%) was similar to that in other series.…”

“…According to this approach, the most important favorable prognostic variables are small tumor size (<5 cm) and low mitotic count (<5/50 HPF) (1,10,13,17,27,28). There is a well-established relationship between these parameters and tumor behavior based on several large clinicopathologic studies (20).…”

“…Though some degree of correlation was found for several features, their reproducibility was poor due to considerable inter-observer variation (15). The presence of a high mitotic count is generally accepted as the best indicator of malignancy (1,7,8,(17)(18)(19).…”

“…There are only a few large series in which the histopathological features of GISTs were studied and correlated with risk groups (13,17,20,21). In a multicenter study, we analyzed 1161 patients with GIST and aimed to determine the histopathological features and immunohistochemical profiles of GISTs in Turkish patients.…”