A fluorescence aptasensor for the sensitive detection of T-2 toxin based on FRET by adjusting the surface electric potentials of UCNPs and MIL-101

Zhao, Xudong; Wang, Yu; Li, Jingzhi; Huo, Bingyang; Huang, Hui; Bai, Jintao; Peng, Yuan; Li, Shuang; Han, Dianpeng; Ren, Shuyue; Wang, Jiang; Gao, Zhixian

doi:10.1016/j.aca.2021.338450

Cited by 57 publications

(20 citation statements)

References 42 publications

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“…Using a combination of energy migration and core–shell structural engineering to improve properties for a wide range of activators would widen the range of applications for lanthanide-doped nanoparticles [ 53 , 54 , 55 ]. Surface modification is required for specific nanomaterials to fulfil various biological activities, in biosciences such as disease therapy (particularly cancer) [ 56 , 57 ], detection [ 58 ], and immunoassay [ 59 ]. Understanding surface functionalization of Ln-doped UCNPs is critical for improving UC efficiency and aqueous solubility [ 60 ].…”

Section: Surface Modification Of Ucnpsmentioning

confidence: 99%

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

et al. 2022

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Upconverting luminescent nanoparticles (UCNPs) are “new generation fluorophores” with an evolving landscape of applications in diverse industries, especially life sciences and healthcare. The anti-Stokes emission accompanied by long luminescence lifetimes, multiple absorptions, emission bands, and good photostability, enables background-free and multiplexed detection in deep tissues for enhanced imaging contrast. Their properties such as high color purity, high resistance to photobleaching, less photodamage to biological samples, attractive physical and chemical stability, and low toxicity are affected by the chemical composition; nanoparticle crystal structure, size, shape and the route; reagents; and procedure used in their synthesis. A wide range of hosts and lanthanide ion (Ln3+) types have been used to control the luminescent properties of nanosystems. By modification of these properties, the performance of UCNPs can be designed for anticipated end-use applications such as photodynamic therapy (PDT), high-resolution displays, bioimaging, biosensors, and drug delivery. The application landscape of inorganic nanomaterials in biological environments can be expanded by bridging the gap between nanoparticles and biomolecules via surface modifications and appropriate functionalization. This review highlights the synthesis, surface modification, and biomedical applications of UCNPs, such as bioimaging and drug delivery, and presents the scope and future perspective on Ln-doped UCNPs in biomedical applications.

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Section: Surface Modification Of Ucnpsmentioning

confidence: 99%

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

et al. 2022

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“…[ 39 ] Apart from PVP, other molecules are also suitable to mediate the growth of UCNP‐MOF heterostructures, such as citrate acid [ 40 ] and poly(ethylenimine). [ 41 ]…”

Section: Controlled Synthesis Of Ucnp‐mof Heterostructuresmentioning

confidence: 99%

“…[ 55 ] Aside from DNA base pairing interactions, π – π stacking interactions were adopted to adsorb aptamer‐modified UCNPs onto the surface of MIL‐101 to construct nanosensors for specific response to T‐2 toxin. [ 41 ]…”

Section: Controlled Synthesis Of Ucnp‐mof Heterostructuresmentioning

confidence: 99%

“…[39] Apart from PVP, other molecules are also suitable to mediate the growth of UCNP-MOF heterostructures, such as citrate acid [40] and poly(ethylenimine). [41] Tan et al demonstrated that carboxylic acid groups anchored on the surface of inorganic NPs through ligand exchange could allow for MOF growth (Figure 2n). [42] By adding the 3,4hydroxycinnamic acid modified UCNPs to a MOF precursor solution, uniform core-shell UCNP@MOF heterostructures could The red ellipses highlighted the dimers in (c).…”

Section: Surface Ligand-mediated Synthesismentioning

confidence: 99%

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Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

Liu

et al. 2021

Advanced Science

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Heterostructure nanoparticles (NPs), constructed by two single‐component NPs with distinct nature and multifunctional properties, have attracted intensive interest in the past few years. Among them, heterostructures made of upconversion NPs (UCNPs) and metal–organic frameworks (MOFs) can not only integrate the advantageous characteristics (e.g., porosity, structural regularity) of MOFs with unique upconverted optical features of UCNPs, but also induce cooperative properties not observed either for single component due to their special optical or electronic communications. Recently, diverse UCNP‐MOF heterostructures are designed and synthesized via different strategies and have demonstrated appealing potential for applications in biosensing and imaging, drug delivery, and photodynamic therapy (PDT). In this review, the synthesis strategies of UCNP‐MOF heterostructures are first summarized, then the authors focus mainly on discussion of their biomedical applications, particularly as PDT agents for cancer treatment. Finally, the authors briefly outlook the current challenges and future perspectives of UCNP‐MOF hybrid nanocomposites. The authors believe that this review will provide comprehensive understanding and inspirations toward recent advances of UCNP‐MOF heterostructures.

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“…antibody and aptamer) as the specific recognition elements have attracted much attention for rapid analysis of diverse targets. Of them, aptamer-based fluorescent sensors, abbreviated as fluorescent aptasensors, with wide applications in different fields ( Fang et al, 2021 , Zhang et al, 2021 , Zhao et al, 2021 ) have provided a preferred choice for OTA detection thanks to their miniature size, portability, excellent sensitivity, rapid response, and low consumption of toxic organic solvents for on-site monitoring.…”

Section: Introductionmentioning

confidence: 99%

Development of a graphene oxide nanosheet and double-stranded DNA structure based fluorescent “signal off” aptasensor for ochratoxin A detection in malt

et al. 2022

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A fluorescence aptasensor for the sensitive detection of T-2 toxin based on FRET by adjusting the surface electric potentials of UCNPs and MIL-101

Cited by 57 publications

References 42 publications

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

Lanthanide-Doped Upconversion Luminescent Nanoparticles—Evolving Role in Bioimaging, Biosensing, and Drug Delivery

Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

Development of a graphene oxide nanosheet and double-stranded DNA structure based fluorescent “signal off” aptasensor for ochratoxin A detection in malt

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