A fluorocarbon-containing hydrophobically associating polymer

Zhang, Y.-X.; Da, A.-H.; Hogen‐Esch, Thieo E.; Butler, George B.

doi:10.1002/pol.1989.140280701

Cited by 40 publications

(54 citation statements)

References 6 publications

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“…These large viscosity decreases upon warming are very different from the temperature responses of solutions of the PAM or PDMA copolymers of FX‐13. For instance, upon heating solutions of FX‐13 PAM copolymers there is first a modest viscosity decrease (factor of three) as the temperature is raised from 25 °C to about 40 °C, followed by a roughly twofold viscosity increase to a maximum at about 60 °C and then a threefold decrease as the temperature is increased to 80 °C 9. 10 Similar behaviour was demonstrated for the corresponding PDMA copolymer solutions 15…”

Section: Resultssupporting

confidence: 56%

“…As illustrated in Fig 1, the B‐14‐3 copolymer seems to be somewhat more strongly associated than the corresponding B‐13‐3 copolymer having about the same MW and comonomer content. The opposite was shown to be the case for the PAM copolymers 9. 10…”

Section: Resultsmentioning

confidence: 90%

“…Aqueous solutions of fluorocarbon‐modified PAM and PDMA copolymers are generally shear‐thinning pseudoplastic fluids 9. 10 However, the B‐14 or B‐13 copolymers with comonomer contents below about 0.30 mol% or the B‐LA copolymers containing 1.5 mol% dodecyl acrylate show all Newtonian behaviour between 0.40 and about 10 s −1 .…”

Section: Resultsmentioning

confidence: 99%

“…This behaviour is completely different from that observed for the PAM or PDMA copolymers which are highly pseudoplastic at all shear rates in excess of 0.40 s −1 (see Discussion). 9–15…”

Section: Resultsmentioning

confidence: 99%

“…Hydrophobic interactions play an important role in surfactant micellation and related phenomena, including association of hydrophobically modified water‐soluble polymers 1–10. Solutions of such polymers containing pendent hydrophobic groups can form polymer clusters by intermolecular hydrophobic association, thereby increasing hydrodynamic volume and thus solution viscosity.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of fluorocarbon-modified poly(N-isopropylacrylamide)

Zhang¹,

Fang²,

Fu³

et al. 2000

Polym. Int.

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Poly(N‐isopropylacrylamide) copolymers (PNIPAMs) containing pendent perfluoroalkyl (RF) or dodecyl groups have been synthesized by copolymerization of NIPAM with small amounts of RR‐acrylates or ‐methacrylates containing a sulfonamido moiety between the acrylate and RF groups or with dodecyl acrylate. Evidence for strong intermolecular hydrophobic association of the fluorocarbon groups is provided by large viscosity increases with copolymer concentration and upon addition of NaCl and surfactants. These interactions appear to be much stronger than that of the corresponding copolymers of poly(N,N‐dimethylacrylamide) with similar comonomer contents. Hydrophobic association between the RF groups is found to be much stronger than that of the corresponding dodecyl groups. The viscosity of some of the copolymer solutions, particularly in the presence of perfluorocarbon surfactants, was unusually temperature sensitive, decreasing by a factor of at least 1000 upon increasing the temperature from 10 to 20 °C. This large decrease is most probably related to the collapse of the copolymer coils near the lower critical solution temperature. This is in sharp contrast to the corresponding polyacrylamide or poly(N,N‐dimethylacrylamide) RF‐acrylate copolymers that show viscosity increases with increasing temperature in the 40–60 °C range. The NIPIAM copolymers were also found to be different from the acrylamide or N,N‐dimethylacrylamide perfluorocarbon acrylate copolymers in that they were found to be Newtonian at a low RF content but dilatant at a higher comonomer content. © 2000 Society of Chemical Industry

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Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of fluorocarbon-modified poly(N-isopropylacrylamide)

Zhang¹,

Fang²,

Fu³

et al. 2000

Polym. Int.

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Hydrophobically Modified Polyelectrolytes, 4. Synthesis and Solution Properties of Fluorocarbon-Containing Poly(acrylic acid)

Zhou¹,

Song²,

Zhang³

et al. 2001

Macromol. Chem. Phys.

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Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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A fluorocarbon-containing hydrophobically associating polymer

Cited by 40 publications

References 6 publications

Synthesis and characterization of fluorocarbon-modified poly(N-isopropylacrylamide)

Synthesis and characterization of fluorocarbon-modified poly(N-isopropylacrylamide)

Hydrophobically Modified Polyelectrolytes, 4. Synthesis and Solution Properties of Fluorocarbon-Containing Poly(acrylic acid)

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

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