A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Hoogedoorn, L.; Gerritsen, Marinel; Wolberink, E.A.W.; Peppelman, Malou; Kerkhof, P.C.M. van de; Erp, P.E.J. van

doi:10.1111/jdv.13627

Cited by 8 publications

(15 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This view is shared by other authors, who also highlighted the necessity to raise awareness of the existing technologies within the medical community, standardize protocols, determine clinically relevant parameters such as sensitivity and specificity in large clinical trials and determine the cost‐effectiveness of the technologies. This approach has been proven successful for RCM, for which a protocol for the diagnosis of chronic plaque psoriasis in dermatological practice has been proposed . The protocol was based on the knowledge of disease features recognizable in RCM images, gained through a series of preliminary clinical studies in psoriasis expertise centres, and on a sound knowledge of relevant literature.…”

Section: Future Perspectives On the Use Of Noninvasive Techniques Formentioning

confidence: 99%

“…This approach has been proven successful for RCM, for which a protocol for the diagnosis of chronic plaque psoriasis in dermatological practice has been proposed. [29] The protocol was based on the knowledge of disease features recognizable in RCM images, gained through a series of preliminary clinical studies in psoriasis expertise centres, and on a sound knowledge of relevant literature. As such challenges will be overcome, and more affordable technological implementations will be brought forward, chances are high that the widespread application of biophysical analysis techniques in dermatological practice and in cosmetic sciences will prove invaluable in offering personalized and noninvasive skin treatment solutions.…”

Section: Future Per S Pec Tive S On the Us E Of Noninva S Ive Technmentioning

confidence: 99%

See 1 more Smart Citation

Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier

Erp

Peppelman

Falcone

2018

Experimental Dermatology

View full text Add to dashboard Cite

In this review, we aim to give a concise and selective overview of noninvasive biophysical analysis techniques for skin barrier analysis (transepidermal water loss, electrical methods, confocal Raman microspectroscopy, sebumeter, reflectance spectrophotometry, tristimulus colorimetry, diffuse reflectance spectroscopy and reflectance confocal microscopy), including advantages and limitations. Rather than giving an exhaustive description of the many techniques currently available, we show the usefulness of a representative selection of techniques in the functional and morphological evaluation of the skin barrier. Furthermore, we introduce human minimally invasive skin challenging models as a means to study the mechanisms regulating skin homoeostasis and disease and subsequently show how biophysical analysis techniques can be combined with these in vivo skin challenging models in the functional and morphological evaluation of the skin barrier in healthy human skin. We are convinced that the widespread application of biophysical analysis techniques in dermatological practice and in cosmetic sciences will prove invaluable in offering personalized and noninvasive skin treatment solutions. Furthermore, combining the human in vivo challenging models with these novel noninvasive techniques will provide valuable methodology and tools for detailed characterization of the skin barrier in health and disease.

show abstract

Section: Future Perspectives On the Use Of Noninvasive Techniques Formentioning

confidence: 99%

Section: Future Per S Pec Tive S On the Us E Of Noninva S Ive Technmentioning

confidence: 99%

Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier

Erp

Peppelman

Falcone

2018

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…The fluorescence scanning confocal microscopy is typically used for imaging in the majority of biological applications [ 68 – 70 ]. The use of reflectance confocal microscopy for tissue imaging is limited, but sometimes it can provide additional information from the samples with significant spatial variation of refractive index [ 71 – 72 ]. It is worth to mention that optical sections are imaged in a focal plane tangential to the tissue surface.…”

Section: Reviewmentioning

confidence: 99%

“…Confocal microscopy has been extensively used in different branches of medicine [ 69 – 72 ]. Due to its ability to provide real-time structural information on superficial layers of tissue this technique was also applied for the detection of precancerous lesions of the uterine cervix [ 73 – 76 ].…”

Section: Reviewmentioning

confidence: 99%

Optical techniques for cervical neoplasia detection

Novikova¹

2017

Beilstein J. Nanotechnol.

View full text Add to dashboard Cite

This paper provides an overview of the current research in the field of optical techniques for cervical neoplasia detection and covers a wide range of the existing and emerging technologies. Using colposcopy, a visual inspection of the uterine cervix with a colposcope (a binocular microscope with 3- to 15-fold magnification), has proven to be an efficient approach for the detection of invasive cancer. Nevertheless, the development of a reliable and cost-effective technique for the identification of precancerous lesions, confined to the epithelium (cervical intraepithelial neoplasia) still remains a challenging problem. It is known that even at early stages the neoplastic transformations of cervical tissue induce complex changes and modify both structural and biochemical properties of tissues. The different methods, including spectroscopic (diffuse reflectance spectroscopy, induced fluorescence and autofluorescence spectroscopy, Raman spectroscopy) and imaging techniques (confocal microscopy, optical coherence tomography, Mueller matrix imaging polarimetry, photoacoustic imaging), probe different tissue properties that may serve as optical biomarkers for diagnosis. Both the advantages and drawbacks of these techniques for the diagnosis of cervical precancerous lesions are discussed and compared.

show abstract

“…4 Descriptive statistics were used to characterize the survey responses. As RCM's use becomes standardized and streamlined into clinical use, 5,6 there may be a need to systematically train residents in the acquisition and interpretation of its images. This national survey is one of the first to characterize RCM's current integration into residency education.…”

mentioning

confidence: 99%

Current Curriculum on Reflectance Confocal Microscopy: a national survey of dermatology faculty and residents

Soh

Pentland

2019

J of Skin

View full text Add to dashboard Cite

Objective:Characterize Reflectance confocal microscopy’s use and curriculum in residency programs. Methods: Observational nine-question survey sent to the Association of Dermatology Professors (APD). Results: Seventy responses were collected with a faculty response rate of 6.6% (29/439). Fifty-four percent of responses indicated RCM is not taught or learned in a meaningful capacity. If RCM is included within curriculum, teaching occurs on average <1-3 times/week versus conventional dermatopathology which is taught on average 1-3 times/week. Nearly fifty percent of responses indicated that RCM is regularly used by faculty. However, seventy percent of respondents did not know if RCM was reimbursable within the practice area. Forty-six percent of respondents saw a need to incorporate RCM into residency curriculum. Conclusions: This national survey is one of the first to characterize RCM’s current integration into residency education. The results suggest that despite a lack of formalized training, there is cautious optimism towards the modality’s usage in dermatologic practice. Given the low faculty response rate, we are cautious to generalize to the greater academic population at this time. Our hope is that this and future studies can survey the need for a standardized RCM curriculum.

show abstract

A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Cited by 8 publications

References 26 publications

Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier

Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier

Optical techniques for cervical neoplasia detection

Current Curriculum on Reflectance Confocal Microscopy: a national survey of dermatology faculty and residents

Contact Info

Product

Resources

About