1972
DOI: 10.1016/0014-5793(72)80381-8
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A fragment corresponding to the CH2 region of immunoglobulin G (IgG) with complement fixing activity

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Cited by 97 publications
(57 citation statements)
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“…1a) (16). A total of 27 (46 chains) antibody crystal structures with coordinates corresponding to the Fc region were identified in the PDB (9) using a structure-based search algorithm (10).…”
Section: Enhancing Antibody Fc Heterodimer Formation Through Electrosmentioning
confidence: 99%
“…1a) (16). A total of 27 (46 chains) antibody crystal structures with coordinates corresponding to the Fc region were identified in the PDB (9) using a structure-based search algorithm (10).…”
Section: Enhancing Antibody Fc Heterodimer Formation Through Electrosmentioning
confidence: 99%
“…Since C1q binds to the CH2 domain within the Fc fragment of IgG (4,5), experiments were conducted to determine whether SP-A inhibits C1q binding to IgG. In our studies, SP-A did not decrease C1q binding to wells coated with the Fc fragment or IC.…”
Section: Sp-a Binds To the Fc Region Of Igg In A Calcium-dependent Mamentioning
confidence: 81%
“…According to this concept, it should be possible to associate specific biological effector functions, such as complement fixation, with a specific submolecular domain in certain immunoglobulin molecules. Evidence to support this hypothesis has been obtained from the data of Connell and Porter (18) and of Ellerson et al (19) demonstrating that the C"y2 domain of IgG contains a C1 binding site (Fig. 2) and (6) (20), and second, the (Fc)5A and Fc,u fragments of IgM were found to have similar complement-fixing capacities in a CH50 assay, each being 31 times as effective as intact IgM by weight and 19 times as effective on a molar basis (21).…”
Section: Introductionmentioning
confidence: 83%