A French View on FISH Painting as a Biodosemeter

Sorokine-Durm, I.; Durand, Valérie; Delbos, M; Baron, Le; Roy, Luke A.; Voisin, P.

doi:10.1093/oxfordjournals.rpd.a033017

Cited by 17 publications

(11 citation statements)

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“…De nombreuses publications attestent que le taux de translocations augmente significativement avec l'âge (Darroudi, 2000 ;Edwards et al, 2005 ;Pressl et al, 1999 ;Ramsey et al, 1995 ;Sigurdson et al, 2008 ;Sorokine-Durm et al, 2000a ;Whitehouse et al, 2005). Ces études peuvent être regroupées en deux groupes : celles regroupant les données issues de plusieurs laboratoires pour avoir plus de poids statistique (Sigurdson et al, 2008 ;Sorokine-Durm et al, 2000b ;Whitehouse et al, 2005), et celles qui présentent les données d'un seul laboratoire (Darroudi et Natarajan, 2000 ;Pressl et al, 1999 ;Ramsey et al, 1995) (Tab.…”

Section: Effet De L'âgeunclassified

“…1). Même si quelques études ont montré une décroissance du taux de translocations avec le temps (Bauchinger et al, 2001 ;Lindholm et Edwards, 2004 ;Sorokine-Durm et al, 2000a ;Tucker, 2008), la stabilité des translocations est incontestablement meilleure que celle des dicentriques Grégoire et al, 2006 ;Lindholm et Edwards, 2004 ;Pala et al, 2001 ;Tawn et al, 2006 ;Tucker, 2008). L'étude de patients traités par radiothérapie durant des dizaines d'années pour spondylarthrite ankylosante, suggère que les translocations semblent persister plusieurs années après l'exposition (Buckton et al, 1962).…”

Section: Introductionunclassified

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Impact des facteurs individuels et environnementaux sur le taux d’aberrations chromosomiques de type translocations Partie 1 : âge, sexe, tabac, alcool

et al. 2010

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The assessment of exposure to ionizing radiation, carried out long time after exposure, is currently performed by scoring of translocations, a specific type of chromosomal aberrations. The translocations rate observed in peripheral blood lymphocytes of exposed subjects is compared to that observed in a control population. However, the translocation specificity towards radiation exposure is not clearly identified. To avoid any hasty conclusion, it is necessary to identify all the factors likely to induce translocation. To our knowledge, no study has thus far examined the effects of all these different factors on translocation rates. A review of the literature thus allowed us to assess the impact of host factors and lifestyle on the production of translocations. This study confirms that age appears to be the factor 1 IRSN, Laboratoire de Dosimétrie Biologique, BP 17, 92262 Fontenay-aux-Roses Cedex, France.Article publié par EDP Sciences E. GRÉGOIRE et al. 154 RADIOPROTECTION -VOL. 45 -N° 2 (2010) having the greatest impact on the rate of translocations, especially over 60 years. To date, the factor "age" is already considered in estimating the impact of radiation on the rate of translocation for all age groups. However, the study also shows that this rate varies significantly when the patient is exposed simultaneously and significantly towards many lifestyle agents. A precise threshold translocation rate should thus be established as a function of known behavioral exposures, below which it is impossible to conclude that radiological exposure has occurred. The effects of chemicals on the translocation rate after occupational exposure will be the subject of a second part.

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Section: Effet De L'âgeunclassified

Section: Introductionunclassified

Impact des facteurs individuels et environnementaux sur le taux d’aberrations chromosomiques de type translocations Partie 1 : âge, sexe, tabac, alcool

et al. 2010

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“…For many years chromosome aberration frequencies have been known to increase with age [16][17][18][19][20], but the relationship between translocation frequencies and age has not been well characterized. More precise estimates of background translocation levels in humans are needed [21,22]. Stable baseline estimates will be very valuable for providing a comparison group to study populations that have been chronically exposed to environmental genotoxins at very low levels.…”

Section: Introductionmentioning

confidence: 99%

International study of factors affecting human chromosome translocations

Sigurdson

Hauptmann

et al. 2008

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Abstract*Correspondence, page proofs, and reprint requests to: James D. Tucker, Ph.D., Department of Biological Sciences, 1370 Biological Sciences Building, 5047 Gullen Mall, Wayne State University, Detroit, TEL: (313) 577-2783, FAX: (313) 577-3602, EMAIL: E-mail: jtucker@biology.biosci.wayne.edu. z Retired Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Chromosome translocations in peripheral blood lymphocytes of normal, healthy humans increase with age, but the effects of gender, race, and cigarette smoking on background translocation yields have not been examined systematically. Further, the shape of the relationship between age and translocation frequency (TF) has not been definitively determined. We collected existing data from sixteen laboratories in North America, Europe, and Asia on TFs measured in peripheral blood lymphocytes by fluorescence in situ hybridization whole chromosome painting among 1933 individuals. In Poisson regression models, age, ranging from newborns (cord blood) to 85 years, was strongly associated with TF and this relationship showed significant upward curvature at older ages vs. a linear relationship (p <0.001). Ever smokers had significantly higher TFs than non-smokers (rate ratio (RR) = 1.19, 95% confidence interval (CI), 1.09-1.30) and smoking modified the effect of age on TFs with a steeper age-related increase among ever smokers compared to non-smokers (p<0.001). TFs did not differ by gender. Interpreting an independent effect of race was difficult owing to laboratory variation. Our study is three times larger than any pooled effort to date, confirming a suspected curvilinear relationship of TF with age. The significant effect of cigarette smoking has not been observed with previous pooled studies of TF in humans. Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes. NIH Public Access

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“…This method is currently considered to be both the most specific and most sensitive for short-term biological dosimetry (Bender et al 1988, Voisin et al 2001, Duran et al 2002. Several months after exposure, however, this conventional cytogenetic method is no longer the most effective way to assess radiation doses, since the frequency of cells carrying these chromosomal aberrations decreases with time after exposure (Sorokine-Durm et al 2000). Dose assessment may therefore be difficult when the time elapsed between exposure and analysis either exceeds one year or is unknown.…”

Section: Introductionmentioning

confidence: 99%