A functional different immune capacity in cattle is associated with higher mastitis incidence

K, Lutterberg; Kjh, Kleinwort; Bf, Hobmaier; Hauck, Stefanie M.; Nüske, Stefan; Am, Scholz; Ca, Deeg

doi:10.1101/311316

2018

DOI: 10.1101/311316

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A functional different immune capacity in cattle is associated with higher mastitis incidence

Lutterberg K

Kleinwort Kjh

Hobmaier Bf

et al.

Abstract: A BVD vaccine with novel production technology and adjuvant was introduced to improve immune responses against BVD. However, 5-10% of vaccinated cattle produced pathogenic antibodies, which transferred bovine neonatal pancytopenia (BNP) via colostrum to almost any calf given respective colostrum. Diseased calves had a very high lethality rate of 90%.

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“…The authors thank Sven Reese for statistical analyses and Roxane Degroote for critical discussions. The manuscript was released as a pre-print at https://www.biorxiv.org/content/early/2018/05/13/311316 (41).…”

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A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence

K¹,

Kleinwort²,

Hobmaier³

et al. 2018

Front. Immunol.

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A novel vaccine against bovine viral diarrhea (BVD) induced pathogenic antibody production in 5–10% of BVD-vaccinated cows. Transfer of these antibodies via colostrum caused Bovine neonatal pancytopenia (BNP) in calves, with a lethality rate of 90%. The exact immunological mechanisms behind the onset of BNP are not fully understood to date. To gain further insight into these mechanisms, we analyzed the immune proteome from alloreactive antibody producers (BNP cows) and non-responders. After in vitro stimulation of peripheral blood derived lymphocytes (PBL), we detected distinctly deviant expression levels of several master regulators of immune responses in BNP cells, pointing to a changed immune phenotype with severe dysregulation of immune response in BNP cows. Interestingly, we also found this response pattern in 22% of non-BVD-vaccinated cows, indicating a genetic predisposition of this immune deviant (ID) phenotype in cattle. We additionally analyzed the functional correlation of the ID phenotype with 10 health parameters and 6 diseases in a retrospective study over 38 months. The significantly increased prevalence of mastitis among ID cows emphasizes the clinical relevance of this deviant immune response and its potential impact on the ability to fight infections.

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mentioning

confidence: 99%

A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence

K¹,

Kleinwort²,

Hobmaier³

et al. 2018

Front. Immunol.

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A functional different immune capacity in cattle is associated with higher mastitis incidence

Cited by 1 publication

References 35 publications

A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence

A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence

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