A functional neuropeptide system in vertebrate gonads: Gonadotropin-inhibitory hormone and its receptor in testes of field-caught house sparrow (Passer domesticus)

McGuire, Nicolette L.; Bentley, G.

doi:10.1016/j.ygcen.2010.01.010

Cited by 92 publications

(85 citation statements)

References 43 publications

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“…Melatonin receptors have been identified in the gonads of birds [21][22][23]. In addition, GnIH peptide and receptor have recently been identified in avian gonads [24], and the addition of melatonin in vitro to testes from European starlings (Sturnus vulgaris) increases the expression of GnIH mRNA within the testes [21], suggesting the possibility for direct actions of melatonin on ovaries as well. In juvenile quail, pinealectomy transiently delayed the onset of oviposition [25].…”

Section: Discussionmentioning

confidence: 99%

Melatonin delays clutch initiation in a wild songbird

et al. 2011

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The hormone melatonin is known to play an important role in regulating many seasonal changes in physiology, morphology and behaviour. In birds, unlike in mammals, melatonin has thus far been thought to play little role in timing seasonal reproductive processes. This view is mainly derived from laboratory experiments on male birds. This study tests whether melatonin is capable of influencing the timing of clutch initiation in wild female songbirds. Free-living female great tits (Parus major) treated with melatonin-filled implants prior to the breeding season initiated their first clutch of the season significantly later than females carrying an empty implant. Melatonin treatment did not affect clutch size. Further, melatonin treatment did not delay the onset of daily activity in the wild nor adversely affect body mass in captivity compared with controls. These data suggest a previously unknown role for this hormone in regulating the timing of clutch initiation in the wild.

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Section: Discussionmentioning

confidence: 99%

Melatonin delays clutch initiation in a wild songbird

et al. 2011

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“…Besides neurons in hypothalamus, the expressions of GNRH1 and GnIH in multiple extrahypothalamic and pituitary sites have been demonstrated (Hsueh & Schaeffer 1985, McGuire & Bentley 2010. These findings suggest that not only GnRH but also GnIH possess multiple functions other than neuroendocrine regulation.…”

Section: Introductionmentioning

confidence: 93%

“…These findings suggest that not only GnRH but also GnIH possess multiple functions other than neuroendocrine regulation. Recently, GnIH or RFRP3 and its receptor were identified in gonads and the accessory reproductive organ of birds and mammals , McGuire & Bentley 2010, Singh et al 2011a). In the testis, the expressions of RFRP3 and its receptor have been demonstrated in rhesus macaque (Macaca mulatta) (Ubuka et al 2009a) and Syrian hamster (Zhao et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice

Anjum

Krishna

Tsutsui

2014

Journal of Endocrinology

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The aim of this study was to evaluate the effects of in vivo and in vitro treatments with RFamide-related peptide 3 (RFRP3), a mammalian gonadotropin-inhibitory hormone ortholog, on testicular activities, i.e. spermatogenesis and steroidogenesis, in mice. Mice were treated in vivo with different doses of RFRP3 (control: 0.02 mg, 0.2 mg, and 2.0 mg/day) for 8 days. For in vitro study, the testes of mice were evaluated with different doses of RFRP3 (control: 1 and 10 ng/ml) with or without LH (control: 10 and 100 ng/ml) for 24 h at 37 8C. RFRP3 treatment produced significant changes in the body mass, circulating steroid level, and testicular activity in mice. RFRP3 treatment also caused dose-dependent histological changes in spermatogenesis, such as decline in germ cell proliferation and survival markers and increase in apoptotic markers in testis. Both in vivo and in vitro studies showed the inhibitory effect of RFRP3 on testosterone synthesis in the testis. RFRP3 inhibited the expression of the receptor for LH (LHCGR), STAR protein, cytochrome P450 side-chain cleavage (CYP11A1) and 3b-hydroxysteroid dehydrogenase in the testis, and testosterone secretion dose dependently. This study also suggested that the inhibitory effect of RFRP3 in the testis may be mediated through local production of GnRH. Thus, RFRP3 inhibits testicular steroidogenesis and spermatogenesis either indirectly through GnRH or by directly influencing germ cell proliferation, survival, and apoptosis.

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“…It is also reported that in vivo administration of GnIH decreases seminiferous tubule diameter and the number of germ cells in quail via suppression of pituitary gonadotropin synthesis and release (Ubuka et al, 2006). The presence of GnIH-R has been detected in the testes and ovaries of several vertebrate species, including birds (McGuire and Bentley, 2010), and putative GnIH binding sites have been demonstrated in the granulosa cell layer by receptor fluorography in birds . GnIH-R mRNA has been localized in the theca and granulosa cells, with significantly lower levels found in preovulatory follicles than in smaller growing follicles (Maddineni et al, 2008).…”

Section: Introductionmentioning

confidence: 95%

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Banerjee

Tsutsui

Chaturvedi

2016

Journal of Experimental Biology

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Reproductive performance of many avian species, including Japanese quail, is reported to be modulated by specific temporal phase relation of serotonergic and dopaminergic oscillations. Accordingly, it has been shown that the serotonin precursor 5-HTP and the dopamine precursor L-DOPA given 8 h apart induce gonadal suppression and given 12 h apart lead to gonadal stimulation, while other temporal relationships were found to be ineffective. In the present study, we investigated the effects of 8-and 12-h phase relation of neural oscillations on testicular responses including expression of GnRH-I, GnIH, pro-apoptotic proteins ( p53 and Bax), inactive and active executioner caspase-3, and the uncleaved DNA repair enzyme PARP-1. Testicular volume and mass decreased significantly in 8-h quail and increased in 12-h quail compared with controls. Expression of ir-GnIH, p53, Bax and active-caspase-3 increased and that of GnRH-I, pro-caspase-3 and uncleaved PARP-1 decreased in 8-h quail compared with controls. A TUNEL assay also confirmed testicular regression in these quail. Testes of 12-h quail exhibited significantly increased expression of GnRH-I, pro-caspase-3 and uncleaved PARP-1 compared with the control group. Our findings suggest that differential response of avian testes to 8-and 12-h phase relation of serotonergic and dopaminergic neural oscillations may be attributed to autocrine/paracrine action of GnIH expression, which is upregulated in regressed testes, leading to apoptotic changes, and downregulated in developed testes, causing apoptotic inhibition. It is concluded that specific phase relation of neural oscillations may modulate the local testicular GnRH-GnIH system and alter the apoptotic mechanism in quail testes. Moreover, these findings highlight the physiological effects of time-dependent drug delivery, including the specific time intervals between two drugs.

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A functional neuropeptide system in vertebrate gonads: Gonadotropin-inhibitory hormone and its receptor in testes of field-caught house sparrow (Passer domesticus)

Cited by 92 publications

References 43 publications

Melatonin delays clutch initiation in a wild songbird

Melatonin delays clutch initiation in a wild songbird

Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

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