A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

Abstract

The melatonin receptor 1B (MTNR1B) polymorphism rs10830963 C>G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect of the polymorphism on the risk of GDM, a meta-analysis therefore was performed. Pooled OR with its corresponding 95%CI was used to estimate the strength of the association. Totally 14 eligible studies with a number of 5033 GDM patients and 5614 controls were included in this meta-analysis. Results indicated that the variant G allele was significantly associated with an increased GDM risk (CG vs. CC: OR = 1.25, 95% CI = 1.11−1.40, P < 0.001; GG vs. CC: OR = 1.78, 95% CI = 1.45−2.19, P < 0.001; G vs. C: OR = 1.33, 95% CI = 1.21−1.47, P < 0.001). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR = 1.15, 95%CI = 1.02−1.28, P = 0.020; GG vs. CC: OR = 1.52, 95% CI = 1.23−1.89, P < 0.001; G vs. C: OR = 1.23, 95% CI = 1.10−1.37, P < 0.001) and in Caucasians (CG vs. CC: OR = 1.40, 95% CI = 1.16−1.70, P < 0.001; GG vs. CC: OR = 2.21, 95% CI = 1.54−3.17, P < 0.001; G vs. C: OR = 1.47, 95% CI = 1.24−1.73, P < 0.001). FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.

Comments on: A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

“…Conflictingly, the authors reported "0.99-0.99-0.99" as OR values [1] -of unknown origin -for our study (labelled as "Rosta et al" on Figures 2-3-4) in the forest plots on the risk of GDM associated with rs10830963 ("CG vs. CC" and "GG vs CC" and "C vs G", respectively). Despite that we did specifically report the minor (G) allele frequencies (MAF) in our study as 0.36 in the GDM group and 0.28 in the control group, these MAF data were apparently also wrongly indicated in the meta-analysis (MAF values of "0.33 and 0.30" in Table 1, respectively).…”

Associations between C-reactive protein and white blood cell count, occurrence of delayed cerebral ischemia and poor outcome following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis

“…Conflict results were also observed with respect to studies on WBC [ 15 , 26 , 30 ]. On the other hand, there is an extensive body of literature identifying blood CRP and WBC as an independent and relatively strong predictive marker for outcomes after ischemic stroke [ 31 – 33 ], it is reasonable for expecting these associations in aSAH.…”

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

“…That may be explained in part by considering that this polymorphism has been consistently associated with a higher risk of gestational diabetes in women [34][35][36]38,40]. In a recent meta-analysis carried out by Huang et al [72], including more than 5000 multi-ethnic gestational diabetes cases and 5000 controls, they confirmed the significant association between the MTNR1B-rs10830963 and gestational diabetes. The estimated OR is 1.47 (1.24-1.73) in Caucasians.…”