A functional variant in the thrombospondin‐1 gene and the risk of small for gestational age infants

Andraweera, Prabha H.; Dekker, Gustaaf A.; Thompson, Steven D.; North, Robyn A.; McCowan, Lesley; Roberts, Claire T.

doi:10.1111/j.1538-7836.2011.04494.x

“…Replacement of an asparagine residue with a serine at residue 700 of TSP1 led to a protein variant that, in cell culture experiments, promoted pro-thrombotic phenomena, including augmented fibrinogen binding and enhanced platelet aggregation (Narizhneva et al 2004). The presence of the TSP-1 A2210G variant has been associated with the small for gestational age phenotype (itself a risk factor for coronary artery disease) in newborns from affected parents (Andraweera et al 2011). Additionally, umbilical cord blood endothelial cells from low birth weight infants (also known to be at risk for cardiovascular disease) were found to overexpress TSP1 and this was associated with decreased angiogenic activity in these cells (Ligi et al 2011).…”

Section: The Cd47-tsp1 Signaling Axis In Human Cvdmentioning

confidence: 99%

Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

Rogers

¹

,

Sharifi‐Sanjani

²

,

Csányi

³

et al. 2014

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Cardiovascular homeostasis and health is maintained through the balanced interactions of cardiac generated blood flow and cross-talk between the cellular components that comprise blood vessels. Central to this cross-talk is endothelial generated nitric oxide (NO) that stimulates relaxation of the contractile vascular smooth muscle (VSMC) layer of blood vessels. In cardiovascular disease this balanced interaction is disrupted and NO signaling lost. Work over the last several years indicates regulation of NO is much more complex than previously believed. It is now apparent the secreted protein thrombospondin-1 (TSP1), that is upregulated in cardiovascular disease and animal models of the same, on activating cell surface receptor CD47, redundantly inhibits NO production and NO signaling. This inhibitory event has implications for baseline and disease-related responses mediated by NO. Further work has identified that TSP1-CD47 signaling stimulates enzymatic reactive oxygen species (ROS) production to further limit blood flow and promote vascular disease. Herein consideration is given to the most recent discoveries in this regard which identify the TSP1-CD47 axis as a major proximate governor of cardiovascular health.

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“…A single nucleotide polymorphism in the TSP-1 gene (TSP-1 2210A/G) was reported to be a significant risk factor for familial premature myocardial infarction, hypertension, and renal disease, which was associated with SGA, suggesting that TSP-1 polymorphism may be associated with the risk of vascular disorders across the course of life. 17 In a rat study, TSP-1 expression was more prominent, especially in peritubular interstitial space. The percentage of glomeruli with positive intraglomerular TSP-1 staining was 19.3 (SD4.5) %; (P<0.0001).…”

Section: Discussionmentioning

confidence: 99%

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Malonda

¹

,

Umboh

²

,

Gunawan

³

2018

PI

0

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Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality. Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age. Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment. Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure. Results Subjects' mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001). Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7 to 8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation. [Paediatr Indones. 2017;57:269-73; doi: http://dx

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“…Similarly, previous publications showed that birth weight was a risk factor for increased TSP-1 levels. 16,17 Isenberg et al reported that the expression of TSP-1 in wild type mice born SGA and aged between 14 to 18 months demonstrated greater degrees of ischemia in the glomeruli and tubulointerstitium of the kidney and formed atherosclerosis in the vessel walls. TSP-1 level was related to birth weight.…”

Section: Discussionmentioning

confidence: 99%

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Malonda¹,

Umboh²,

Gunawan³

2018

PI

0

View full text Add to dashboard Cite

Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality. Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age. Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment. Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure. Results Subjects' mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001). Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7 to 8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation. [Paediatr Indones. 2017;57:269-73; doi: http://dx

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A functional variant in the thrombospondin‐1 gene and the risk of small for gestational age infants

Cited by 22 publications

References 33 publications

Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

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